Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.
Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection. C6 peptide refers to the sixth invariant region (C6) of the variable major protein-like sequence-expressed (VLsE) lipoprotein of B. Burgdorferi may be more sensitive in patients with erythema migrans.
Borrelia burgdorferi LFA-1 (Lymphocyte Function Antigen 1): Own body protein + Borrelia burgdorferi sensu stricto (shared epitope). Often associated with autoimmune diseases: collagenosis, Rheumatoid Arthritis, vasculitis (ANA, CCP antibodies, ANCA) It helps to decide whether the patient is suffering from an active infection or an autoimmune disease.
one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease
Borrelia burgdorferi p30 - IgG Marker: A Critical Indicator for Lyme Disease Diagnosis The Borrelia burgdorferi p30 - IgG marker is an antibody test used to detect exposure to Borrelia burgdorferi, the bacterium responsible for Lyme disease. This specific marker targets the p30 protein, a key antigen expressed by Borrelia burgdorferi. The presence of IgG antibodies against the p30 protein indicates that the body has encountered the bacteria, typically during an active or past infection. What Does an Elevated p30 - IgG Marker Indicate? An elevated Borrelia burgdorferi p30 - IgG result suggests that the individual has been exposed to Borrelia burgdorferi and has developed an immune response, producing IgG antibodies. These antibodies typically indicate a past or chronic infection, as IgG is the antibody type associated with long-term immunity or immune memory. Unlike some other Lyme disease markers, the p30 protein is highly specific to Borrelia burgdorferi, making it a useful tool in confirming a Lyme disease diagnosis. Elevated levels of Borrelia burgdorferi p30 - IgG may indicate the presence of a persistent or chronic infection, as IgG antibodies are often detectable after the initial acute phase of Lyme disease, even if symptoms are not currently active. The Role of the p30 Protein in Lyme Disease The p30 protein is an integral part of the bacterium’s outer structure, contributing to its ability to invade and persist within the body. Because this protein is unique to Borrelia burgdorferi, detecting antibodies against it provides a strong indication of Lyme disease exposure. The p30 - IgG test is often used in conjunction with other Lyme disease tests to provide a comprehensive assessment of the infection. Importance of the p30 - IgG Marker in Lyme Disease Testing The Borrelia burgdorferi p30 - IgG marker is particularly useful in cases where other Lyme disease markers, like VlsE1, may not provide clear results. Since p30 is specific to Borrelia burgdorferi, it can help confirm the diagnosis, especially in cases of chronic or late-stage Lyme disease. Elevated p30 - IgG levels, when considered alongside clinical symptoms and other diagnostic tests, can help healthcare providers determine whether Lyme disease is contributing to a patient’s health concerns. Conclusion The Borrelia burgdorferi p30 - IgG marker is an important diagnostic tool for identifying exposure to Borrelia burgdorferi, the bacterium responsible for Lyme disease. Elevated levels of IgG antibodies against the p30 protein suggest a past or chronic infection, providing valuable insight into the presence of Lyme disease. If you have elevated test results for p30 - IgG, it’s essential to consult a healthcare provider for further evaluation and appropriate treatment to address the potential effects of Lyme disease.
What is Borrelia burgdorferi p30 – IgM? The p30 – IgM marker measures early immune system activity against the p30 protein of Borrelia burgdorferi, the bacterium responsible for Lyme disease. The "p30" refers to a 30-kilodalton protein expressed by the bacterium, which serves as one of several antigens used in serologic testing to detect the body’s immune response. IgM antibodies are produced during the early stages of infection—typically within the first 1 to 2 weeks following exposure. Therefore, the presence of IgM antibodies to the p30 protein may indicate that your immune system is actively responding to a recent or ongoing Borrelia infection.
Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection. Outer surface protein A (OspA) is one of the major proteins in the outer membrane of this B. burgdorferi. A vaccine based OspA was approved by the FDA in 1998. Individuals vaccinated subcutaneously showed approximately 76% protection agains B. burgdorferi infection after receiving three vaccine doses; however, the human vaccine was removed from the market later.
one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease
one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease.
Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection. B. burgdorferi p66 is an outer membrane spanning protein Oms66. It is proven to be an integral membrane porin because liposome-reconstituted P66 displayed channel-forming activity in planar lipid bilayer assays. P66 has also been shown to function as an adhesin that binds the mammalian cell receptors, B3 chain and B1 chain integrins.
Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection. B. burgdorferi p66 is an outer membrane spanning protein Oms66. It is proven to be an integral membrane porin because liposome-reconstituted P66 displayed channel-forming activity in planar lipid bilayer assays. P66 has also been shown to function as an adhesin that binds the mammalian cell receptors, B3 chain and B1 chain integrins.
Borrelia burgdorferi p83-93 IgG – Tickborne Diseases Panel (Vibrant America) What is it? The Borrelia burgdorferi p83-93 IgG marker detects the presence of IgG antibodies against a specific protein (p83-93) found in Borrelia burgdorferi, the bacterium that causes Lyme disease. This protein is associated with the late stages of Lyme disease and is considered highly specific to Borrelia. What does p83-93 mean? The numbers “p83-93” refer to a protein with a molecular weight of 83 to 93 kilodaltons, which is strongly immunogenic. It is typically expressed during later phases of infection, and the body produces IgG antibodies in response. Why is this marker important? A positive p83-93 IgG result may indicate a long-standing or late-stage infection with Borrelia burgdorferi. IgG antibodies generally take weeks to develop, so this marker is not used to detect early infection but rather to assess chronic or past exposure. Elevated or positive IgG p83-93 may suggest: Late-stage Lyme disease, especially with neurological, cardiac, or joint symptoms Persistent immune response following prior infection Previous Borrelia exposure, even if current symptoms are not present Limitations and context: A positive result should be interpreted alongside clinical symptoms and other Borrelia-specific markers (such as p41, p18, OspC) False positives can occur, though p83-93 is considered relatively specific to Lyme disease A full clinical evaluation and possibly confirmatory testing (Western blot, PCR, or C6 peptide ELISA) are recommended Who should be tested? This marker is most useful for individuals who: Have unexplained chronic fatigue, joint pain, or neurological symptoms Suspect long-term Lyme disease Have been exposed to tick-endemic areas and have persistent health issues Clinical note: A positive p83-93 IgG result alone does not confirm active infection—it reflects immune memory. It must be interpreted in the broader clinical context.
Borrelia burgdorferi p83-93 (IgM) – Tickborne Disease Panel (Vibrant America) What is it? The Borrelia burgdorferi p83-93 (IgM) marker tests for IgM antibodies against the p83-93 protein of Borrelia burgdorferi, the bacterium responsible for Lyme disease. IgM antibodies typically appear early in an infection and signal an active or recent immune response. What does p83-93 mean? The p83-93 protein is a high molecular weight antigen (83 to 93 kilodaltons) found on Borrelia burgdorferi. It is most often associated with late-stage Lyme disease, although detection of IgM against this protein can occasionally appear in early stages if the immune response is robust. What does a positive IgM p83-93 result mean? May indicate an early or active immune response to Borrelia May suggest recent exposure to Lyme disease In some cases, IgM responses may persist beyond the acute phase, potentially reflecting ongoing immune activation Should be interpreted with caution, as IgM tests are more prone to false positives, especially in the absence of symptoms Why is it important? While p83-93 is more typically linked with chronic or late Lyme disease in the IgG phase, detection of IgM antibodies against this protein can occur early in infection or during reactivation. However, because IgM antibodies can remain elevated for weeks or months—and can cross-react with other infections—clinical correlation is essential. Elevated p83-93 IgM levels may suggest: Early Lyme disease, particularly within 1–4 weeks of infection Recent Borrelia exposure with an ongoing immune response A possible false-positive in individuals with other infections or autoimmune conditions Important context for interpretation: A positive IgM without symptoms or without other Borrelia markers may not indicate true infection Best interpreted alongside clinical history, symptoms (e.g., fever, rash, joint pain, neurological issues), and other Lyme-specific antibodies Confirmatory testing (e.g., immunoblot or PCR) is often recommended Who should consider this test? Individuals who: Have early signs of Lyme disease (e.g., erythema migrans rash, flu-like symptoms) Have been in tick-endemic areas within the past few weeks Are experiencing acute, unexplained symptoms after potential tick exposure Clinical note: The IgM response alone should not be used to diagnose Lyme disease without supportive symptoms or additional positive markers. Over-reliance on IgM testing can lead to misdiagnosis if not carefully interpreted.
one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease
