→ CD45 is a surface marker expressed on all leukocytes, including lymphocytes, monocytes, and granulocytes. It is an important marker for signal transduction and cell function.
→ CD45 is used for gating. This means that the CD45 marker is employed to define and isolate specific cell subsets, particularly lymphocytes, during flow cytometry analysis, as it helps distinguish these cells from other blood or tissue components. Gating on the CD45-positive cell population is a common strategy to identify and analyze lymphocytes, as it helps separate them from other cell types that may be present in the sample.
The Absolute CD45 Count is a specific measurement that provides crucial information about your immune system's health. The CD45 marker is found on the surface of lymphocytes, which are a type of white blood cell playing a vital role in your body's immune response. When you hear "absolute," it refers to the actual number of cells that carry the CD45 marker in a given volume of blood, typically measured per microliter.
This count is essential because it helps doctors understand how many of these important immune cells are present in your body. A healthy immune system has a certain range of CD45 cells to fight infections and diseases effectively. If the Absolute CD45 Count is too high or too low, it might indicate an underlying condition or an immune system that isn't functioning as well as it should be. For example, a low count could suggest a weakened immune system, making you more susceptible to infections, while a high count could indicate an immune system that is overactive, which can occur in various conditions, including some autoimmune diseases. By measuring this count, healthcare providers can get valuable insights into your immune health, aiding in the diagnosis, monitoring, and sometimes the treatment planning of diseases affecting the immune system.
Reference Ranges:
18-55 years: 0.99-3.15 thou/mcL
>55 years: 1.00-3.33 thou/mcL
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Reference Ranges:
18-55 years: 0.99-3.15 thou/mcL
>55 years: 1.00-3.33 thou/mcL
In the context of using the CD45 marker for gating during flow cytometry—an analytical process to identify and categorize cells based on specific markers—the relevance of CD45 levels being too high or too low takes on a distinct significance. Gating is a technique used to separate cell populations based on their characteristics, such as the presence or absence of specific markers like CD45.
When CD45 is used for gating, it serves as a crucial identifier for lymphocytes and other immune cells. The level of CD45 expression (how much of this marker is present on the cell surface) can significantly impact the gating process. High levels of CD45 could indicate a robust population of immune cells, possibly reflecting an active immune response or certain immune system disorders where there is an overproduction of lymphocytes. On the other hand, low levels of CD45 might suggest a reduced immune cell population, indicating conditions where the immune system is compromised or suppressed.
Thus, in flow cytometry, the expression level of CD45 is essential for accurately identifying and quantifying different cell populations. It helps in distinguishing between various types of immune cells and understanding the state of the immune system, whether it's actively responding to an infection, affected by a disorder, or compromised due to a treatment or condition. This detailed insight is invaluable for diagnosis, monitoring disease progression, and tailoring treatments to specific immune-related conditions.
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Reference Ranges:
18-55 years: 0.99-3.15 thou/mcL
>55 years: 1.00-3.33 thou/mcL
When the Absolute CD45 Count from a Lymphocyte panel is low, it means your body might not have enough lymphocytes, a type of white blood cell crucial for fighting off infections and diseases. This condition, known as lymphocytopenia or lymphopenia, can happen for several reasons. It might be due to immune system disorders like HIV/AIDS, which significantly weaken your immune defense, or because of treatments like chemotherapy or radiation therapy for cancer, which can damage the bone marrow where these cells are made. Sometimes, autoimmune diseases, where the body attacks itself by mistake, or severe infections that use up a lot of these cells in the fight against illness, can also lead to lower lymphocyte counts. Even being born with certain conditions that affect lymphocyte production or not getting enough essential nutrients like zinc, copper, and vitamin B12 can impact the number of these cells. However, just one low count doesn't immediately point to a problem; doctors will look at this number alongside other tests and your health history to figure out what's going on and what to do about it.
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In the context of using the CD45 marker for gating during flow cytometry—an analytical process to identify and categorize cells based on specific markers—the relevance of CD45 levels being too high or too low takes on a distinct significance. Gating is a technique used to separate cell populations based on their characteristics, such as the presence or absence of specific markers like CD45.
When CD45 is used for gating, it serves as a crucial identifier for lymphocytes and other immune cells. The level of CD45 expression (how much of this marker is present on the cell surface) can significantly impact the gating process. High levels of CD45 could indicate a robust population of immune cells, possibly reflecting an active immune response or certain immune system disorders where there is an overproduction of lymphocytes. On the other hand, low levels of CD45 might suggest a reduced immune cell population, indicating conditions where the immune system is compromised or suppressed.
Thus, in flow cytometry, the expression level of CD45 is essential for accurately identifying and quantifying different cell populations. It helps in distinguishing between various types of immune cells and understanding the state of the immune system, whether it's actively responding to an infection, affected by a disorder, or compromised due to a treatment or condition. This detailed insight is invaluable for diagnosis, monitoring disease progression, and tailoring treatments to specific immune-related conditions.
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% CD19 (B Cells), % CD3 (Mature T Cells), % CD3+CD25+ Lymphs, % CD4, % CD8, Abs.CD3+CD25+ Lymphs, Absolute CD19+ Cells, Absolute CD3+ Cells, Absolute CD4+ Cells, Absolute CD45 Count, Absolute CD8+ Cells, Absolute Lymphocytes, Absolute T-Suppressor Cells, Activated CD21 low CD38- %, Activated CD21 low CD38- Abs, CD20+ %, CD20, Abs Count, CD3-/CD16+CD56+ (%), CD3-/CD16+CD56+ (Absolute), CD4/CD8 Ratio, CD57+ NK-cells (%), CD57+ NK-cells (absolute), Class-switched CD27+IgD-IgM- %, Class-switched CD27+IgD-IgM- Abs, Lymph CD16&56 (NK) %, Lymphocyte Absolute CD16&56 (NK) Count, NATURAL KILLER CELLS CD3-CD16+CD56+ (ABS), NK Cells (CD16/CD56), Non switched CD27+IgD+IgM+ %, Non switched CD27+IgD+IgM+ Abs, Plasmablasts CD38+IgM- %, Plasmablasts CD38+IgM- Abs, T-Helper/Suppressor Ratio, Total Memory CD27+ %, Total Memory CD27+ Abs, Total NK Cells (CD16/CD56), Transitional CD38+IgM+ %, Transitional CD38+IgM+ Abs
