The anti-Hu antibody is the most frequent manifestation of sensory neuropathy with frequent autonomic involvement. The clinical patterns of the neuropathies is in keeping with accordance with the cellular distribution of the HuD antigen.
→ Antibodies to Hu, Ri and Yo antigens are present in patients with paraneoplastic neurologic syndrome such as encephalomyelitis.
→ Hu antibodies are frequently associated with small cell lung cancer and neuroblastoma.
→ Hu antibodies are rarely associated with non-small cell lung cancer, prostate cancer or seminoma.
References:
Li J, Lin W. Various clinical features of patients with anti-Hu associated paraneoplastic neurological syndromes: An observational study. Medicine (Baltimore). 2018 May;97(18):e0649. doi: 10.1097/MD.0000000000010649. PMID: 29718880; PMCID: PMC6392975.
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→ Antibodies to Hu, Ri and Yo antigens are present in patients with paraneoplastic neurologic syndrome such as encephalomyelitis.
→ Hu antibodies are frequently associated with small cell lung cancer and neuroblastoma.
→ Hu antibodies are rarely associated with non-small cell lung cancer, prostate cancer or seminoma.
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Anti-Acetylcholine receptors (IgG + IgA), Anti-Acetylcholine receptors (IgM), Anti-Amphiphysin (IgG + IgA), Anti-Amphiphysin (IgM), Anti-Aquaporin 4 (IgG + IgA), Anti-Aquaporin 4 (IgM), Anti-Cerebellum (IgM), Anti-Contactin-associated protein-like 2 antibodies (IgG + IgA), Anti-Contactin-associated protein-like 2 antibodies (IgM), Anti-CV2 (IgG + IgA), Anti-CV2 (IgM), Anti-Endothelin A receptor (IgM), Anti-Glial fibrillary acidic protein (IgG + IgA), Anti-Glial fibrillary acidic protein (IgM), Anti-Glucose regulated protein 78 (IgG + IgA), Anti-Glucose regulated protein 78 (IgM), Anti-Glycine receptor (IgG + IgA), Anti-Glycine receptor (IgM), Anti-GM1 (IgG + IgA), Anti-GM1 (IgM), Anti-GM2 (IgG + IgA), Anti-GM2 (IgM), Anti-Hu (IgG + IgA), Anti-Hu (IgM), Anti-Hydroxytryptamine (IgM), Anti-MAG (IgG + IgA), Anti-MAG (IgM), Anti-Microglia (IgG + IgA), Anti-Microglia (IgM), Anti-Muscle specific kinase (IgG + IgA), Anti-Muscle specific kinase (IgM), Anti-Myelin basic protein (IgG + IgA), Anti-Myelin basic protein (IgM), Anti-Myelin oligodendrocyte glycoprotein (IgG + IgA), Anti-Myelin oligodendrocyte glycoprotein (IgM), Anti-Myelin proteolipid protein (IgG + IgA), Anti-Myelin proteolipid protein (IgM), Anti-Neurofascin (IgG + IgA), Anti-Neurofascin (IgM), Anti-Neuron specific enolase (IgG + IgA), Anti-Neuron specific enolase (IgM), Anti-Purkinje cell, Anti-Recoverin (IgG + IgA), Anti-Recoverin (IgM), Anti-Ri (IgG + IgA), Anti-Ri (IgM), Anti-s100b (IgG + IgA), Anti-s100b (IgM), Anti-Streptococcal A (IgG), Anti-Tubulin (IgG + IgA), Anti-Tubulin (IgM), Anti-Voltage gated calcium channels (IgG + IgA), EBNA1 (IgG), p18 (IgG), VCA gp125 (IgG)