The diagnosis of cerebrospinal fluid (CSF) rhinorrhea or otorrhea (leakage of CSF into the nose or ear canal, usually as a result of head trauma, tumor, congenital malformation, or surgery) is often difficult to confirm. Traditional chemical analyses (eg, glucose, protein, specific gravity) are unreliable. Radiographic studies, especially those involving the injection of dyes or radiographic compounds, are costly and may introduce additional risks to the patient.
Transferrin that migrates in the beta-1 electrophoretic fraction (beta-1 transferrin) is found in most body fluids. Beta-2 transferrin is a CSF-specific variant of transferrin and is used as an endogenous marker of CSF leakage. Beta-2 transferrin is formed by loss of sialic acid due to the presence of neuraminidase in the central nervous system. Beta-2 transferrin has also been called CSF-specific transferrin and tau protein.
Prompt diagnosis and localization facilitates appropriate decisions and decreases the risk of meningitis.
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21-Hydroxylase Antibodies, Acetoacetate, S/P, Acetylcholine Receptor Ganglionic (Alpha 3) AB, Adamts13 Activity, Alpha 2 Antiplasmin, Ana Pattern, AnaChoice Screen, Arachidonic Acid, B2 GLYCOPROTEIN I (IGA)AB, B2 GLYCOPROTEIN I (IGG)AB, B2 GLYCOPROTEIN I (IGM)AB, Beta 2 Transferrin, Beta-Hydroxybutyrate, Copeptin, CORTISOL,FREE,LC/MS,S, DNA Ab (ds) Crithidia, IFA, EPA/ARACHIDONIC ACID Ratio, ESTRADIOL (Quest), G-6-PD, RBC, GLUCOSE-6-PHOSPHATE DEHYDROGENASE, Glutamic Acid Decarboxylase 65 AB, Gluten (F79) IgG, Helicobacter Pylori, Urea Breath Test, Hexagonal Phase Confirm, HISTAMINE, PLASMA, IGF 1, LC/MS, IMMUNOGLOBULIN M, Immunoglobulin Subclass 4, Lactic Acid, Plasma, LH, Lithium, LKM-1 Antibody (IgG), LUPUS ANTICOAGULANT, Metanephrine, Free, Mutated Citrullinated Vimentin (MCV) Ab, Neuron Specific Enolase (NSE), Normetanephrine, Free, NT PROBNP, OH-Hexanoylcarnitine, C6OH, OMEGA 3 (EPA+DHA) INDEX, OMEGA 6/OMEGA 3 Ratio, Parathyroid Hormone, intact, PARTIAL THROMBOPLASTIN TIME, ACTIVATED, PREGNENOLONE, LC/MS, PROGESTERONE, LC/MS, Prostaglandin D2 (PG D2), Urine, Prostaglandin E2, Serum/Plasma, PROSTAGLANDINS (PG D2), SERUM/PLASMA, PROSTAGLANDINS: (PLASMA/SERUM), PROTHROMBIN ANTIBODY (IGG), Selenium, Soluble Liver Antigen (SLA) Autoantibody, T3 Reverse, LC/MS/MS, T3, FREE, Total Glutathione, Total, Free (MN+NMN), TRYPTASE, TSI - Thyroid-Stimulating Immunoglobulin, Serum, Vascular Endothelial Growth Factor (VEGF), Z SCORE (FEMALE), Z SCORE (MALE)