What is C-reactive protein (CRP)?
C-reactive protein (CRP) is a protein the liver produces in the presence of infection or inflammatory disease such as rheumatoid arthritis. When you have an infection, the white blood cells act to fight it by producing a number of proteins, some of which stimulate the liver to produce CRP. The blood level of CRP has been used for many years to evaluate the level of inflammation or infection.
How does CRP relate to cardiovascular risk?
Your level of C-reactive protein can be an indicator of how at risk you are for developing cardiovascular problems. This is because the development of atherosclerosis (laying down of cholesterol inside the blood vessel walls) is associated with inflammation within the vessel walls. The result is higher levels of CRP in patients with atherosclerosis than in those without atherosclerosis.
The value of knowing CRP levels depends on whether you fall into one of three cardiovascular risk groups:
Low risk – because of low cholesterol levels and little history of risk factors; that is, no diabetes, high blood pressure, or smoking, and no family history of heart attacks at an early age. Even a higher level of CRP will probably not put you at a level of risk that requires than lifestyle changes.
Intermediate risk – helpful to know CRP level, because it can provide missing piece of information for physician deciding next step in treatment
High risk – not essential to know your CRP, because you should already be combining aggressive treatment with lifestyle changes to lower your risk
Reference ranges:
Average hs-CRP level:
- Low risk: <1.00 mg/L
- Average risk: 1.00−3.00 mg/L
- High risk: >3.00 mg/L
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A high C-reactive protein (CRP) cardiac level signifies an increased risk of developing cardiovascular problems, particularly atherosclerosis, which is the laying down of cholesterol inside the blood vessel walls. CRP is a protein produced by the liver in response to inflammation or infection in the body. In the context of cardiovascular risk assessment, elevated CRP levels are associated with inflammation within the vessel walls, which is indicative of atherosclerosis.
The value of knowing CRP levels depends on the individual's cardiovascular risk group:
Levels less than 1 are considered low, 1-3 are intermediate, and 3 or greater are considered high. High-sensitivity CRP (hs-CRP) tests are more sensitive than standard CRP tests and can detect smaller increases in CRP.
An elevated hs-CRP level in the blood has been linked to an increased risk of heart attacks, and people who have had a heart attack are more likely to experience another one if they have a high hs-CRP level. However, hs-CRP testing is not recommended for everyone. It may be most useful for individuals with a 10% to 20% chance of having a heart attack within the next 10 years (known as intermediate risk), as it can help doctors determine if more intensive treatment is required.
It's important to note that inflammation due to other conditions, such as infections, illnesses, or severe arthritis flare-ups, can also elevate CRP levels. Therefore, it's essential to inform your doctor about other medical conditions.
For individuals with moderate or high CRP levels and at risk of heart disease, making lifestyle changes is crucial. These changes include following a heart-healthy diet, managing high cholesterol, maintaining a healthy weight, regular exercise, quitting smoking, managing diabetes or high blood pressure, and drinking alcohol responsibly.
Statins, which are cholesterol-lowering medications, may be prescribed for those with high CRP levels to reduce the risk of heart disease. However, the decision to use statins should be made in consultation with a healthcare provider, taking into account other risk factors and individual health status.
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11dhTxB2/Creatinine (AspirinWorks), Absolute Reticulocytes, Alpha-1 Antitrypsin Phenotype, Alpha-1-Antitrypsin, Serum, Ammonia, Angiotensin-1-Converting Enzyme, Beta-2 Glycoprotein I Ab, IgA, Beta-2 Glycoprotein I, IgG, Beta-2 Glycoprotein I, IgM, Bicarbonate (HCO3), Serum, C-Reactive Protein (CRP), C-Reactive Protein, Cardiac, Copper, Serum or Plasma, D-Dimer, D-Dimer, Quantitative, Delta Aminolevulinic Acid, Urine, 24 Hour, Erythropoietin (EPO), Serum, F2-Isoprostane, Factor IX Activity, Factor V Leiden Mutation, Factor VII Activity, Factor VIII Activity, Factor X Activity, Factor XI Activity, Ferritin, Ferritin (female range), Fibrinogen Activity, Fibrinogen Antigen, Glucose 6-Phosphate Dehydrogenase (G6PD), Quantitative, Haptoglobin, Hemoglobin A, Hemoglobin F, Immatue Reticulocyte Fraction, Immature Platelet Fraction, Immature Retic Fraction, Iron, IRON (Serum), Lactate Dehydrogenase (LDH or LD), Large Unstained Cells (LUC), Large Unstained Cells (Percent), Macrocytosis, Magnesium, RBC, Nucleated RBC (NRBC) (%), Nucleated red blood cell (NRBC), OxPL-apoB1, Plasminogen Activator Inhibitor 1 (PAI-1) Activity, Platelet Ab, Indirect (IgA), Platelet Ab, Indirect (IgG), Platelet Ab, Indirect (IgM), Plateletcrit (PCT), Polychromasia, Porphobilinogen Deaminase, Whole Blood, Porphyrins, Total Serum, PTT-LA Screen, Retic Hgb Equivalent, Reticulocyte Count, Reticulocyte hemoglobin, Reticulocyte, Absolute, Sickle Cell Screen, Stomatocytes, Thrombin Antithrombin Complex, Thrombocytes, Total iron-binding capacity (TIBC), Transferrin, Transferrin Receptor, Transferrin saturation (Iron Saturation), UIBC
