A healthy result should fall into the range 15 - 44 µmol/L.

Citrulline is an amino acid made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family (NOS).

Citrulline gets its name from its high concentration in the watermelon Citrullus vulgaris.

In human kidneys, citrulline and aspartic acid are united by argininosuccinate synthetase (ASS) to produce arginosuccinate. The degradation of arginosuccinate to fumarate and arginine is a primary mechanism for sustaining plasma levels of arginine. The same enzyme acts in liver cells to complete the urea cycle. Plasma citrulline has been used as a marker for reduced small intestinal mass, intestinal injury and rejection of small bowel transplants. Plasma citrulline rises in proportion to enterocytes mass, reflecting the unique capacity of enterocytes for net conversion of glutamine into citrulline.

Both classic and type II citrullinemia are associated with known gene alterations. Plasma citrulline elevation is also used as a marker of postoperative intestinal failure. Nitric oxide (NO) synthesis from arginine results in lower production of citrulline. Low availability of NO may be due to inactivation of NO or inhibition of synthesis, which may be detected by lowered production of citrulline.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833233/

Citrulline result calculator

insert the value from you Citrulline test result.

What does it mean if your Citrulline result is too low?

If aspartic acid, citrulline, and to a lesser extent, arginine are on the low side, these results would  be consistent with an elevated rate of consumption of amino acids for  fuel. They are all involved in the urea cycle, which converts ammonia to urea. Ammonia is generated when amino acids are burned as fuel.

What does it mean if your Citrulline result is too high?

High plasma or urinary citrulline can indicate a functional enzyme block in the urea cycle, leading to an ammonia buildup. Supplement magnesium and aspartic acid add to drive the cycle. Lower protein intake is suggested in ammonia toxicities.

Are you concerned about your lab report?
Select your plan, upload your lab reports and we’ll provide you with a meaningful interpretation.

Basic Interpretation
  • Instant interpretation
  • Use self upload form
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
Full Interpretation
  • Instant interpretation
  • We upload 4 reports for you
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
  • Online support
Own It For Life
  • Unlimited access
  • No subscription
  • Instant interpretations
  • We upload 10 reports for you
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Test results don't lie. Learn what is happening inside your body.

Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.

Get Started

WE SUPPORT 1000+ BIOMARKERS INCLUDING BIOMARKERS FROM YOUR FAVOURITE LABS


"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."


"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."


"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."



Pricing

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.