Clostridiales Incertae Sedis IV, identified in a gut microbiome test, is a group of bacteria within the Clostridiales order whose specific classification is uncertain ('Incertae Sedis' literally means 'of uncertain placement'). This group is part of the complex and diverse gut microbiome, playing a role in the intricate ecosystem of the human gastrointestinal tract. Bacteria in the Clostridiales order are generally known for their anaerobic properties and ability to ferment various substrates, contributing to the production of important metabolites like short-chain fatty acids (SCFAs), which are crucial for maintaining gut health.
The presence and abundance of Clostridiales Incertae Sedis IV can be influenced by several factors, including diet, overall health, and gut environment. Dietary habits, particularly the intake of fibers and other fermentable substrates, can significantly affect their growth and activity. Additionally, factors like antibiotic use, which can disrupt the gut microbiota balance, and health conditions that alter gut physiology, can impact their levels.
While the specific roles and functions of Clostridiales Incertae Sedis IV are not fully understood due to their uncertain classification, they are believed to contribute to the fermentation processes in the gut. This fermentation is vital for breaking down dietary components that are indigestible by human enzymes, aiding in nutrient absorption, and supporting colon health. However, imbalances in these bacteria, either through overgrowth or depletion, could potentially be linked to gut health issues, although the exact implications are still being researched.
Addressing imbalances in the levels of Clostridiales Incertae Sedis IV involves approaches similar to those used for managing general gut microbiota health. Dietary modifications, such as increasing the intake of diverse fibers, can encourage a healthy and balanced gut microbiome. Probiotic and prebiotic supplements may also be beneficial in restoring and maintaining gut microbial diversity.
In cases where an imbalance of Clostridiales Incertae Sedis IV is suspected to be associated with specific gastrointestinal symptoms or conditions, healthcare professionals may suggest additional diagnostic testing or targeted treatments. These might include personalized dietary recommendations or specific probiotic formulations tailored to individual needs.
References:
Scheperjans F, Aho V, Pereira PA, Koskinen K, Paulin L, Pekkonen E, Haapaniemi E, Kaakkola S, Eerola-Rautio J, Pohja M, Kinnunen E, Murros K, Auvinen P. Gut microbiota are related to Parkinson's disease and clinical phenotype. Mov Disord. 2015 Mar;30(3):350-8. doi: 10.1002/mds.26069. Epub 2014 Dec 5. PMID: 25476529. [L]
Elevated levels of Clostridiales Incertae Sedis IV in the gut can be indicative of certain imbalances or changes in the gut microbiota, although the specific implications of this particular group are not fully understood due to its 'Incertae Sedis' status (meaning its precise classification is uncertain). Generally, the Clostridiales order is known for its anaerobic bacteria that play significant roles in the gut, such as fermenting undigested carbohydrates and contributing to the production of short-chain fatty acids (SCFAs), crucial for gut health.
The causes for an increase in Clostridiales Incertae Sedis IV can be multifactorial. Dietary habits are a major influencer; a diet rich in certain fibers may encourage the growth of these bacteria. Other factors include overall gut health, the use of antibiotics or other medications that disrupt gut flora, and individual health conditions that can alter the gut environment.
The implications of elevated levels of these bacteria are not entirely clear and can be complex. While the production of SCFAs is generally beneficial, an overgrowth of certain bacteria within the Clostridiales order might disrupt the delicate balance of the gut microbiome. This imbalance can potentially contribute to gastrointestinal issues like bloating, gas, and discomfort. It may also be associated with broader health issues, considering the gut microbiota's role in overall health.
Addressing elevated levels of Clostridiales Incertae Sedis IV typically involves rebalancing the gut microbiota. Dietary modifications are often the first approach, involving a balanced intake of fibers and other nutrients to support a diverse microbial community. Probiotics and prebiotics can also be beneficial. Probiotics introduce beneficial strains of bacteria, while prebiotics provide the necessary nutrients for gut bacteria to thrive.
Lifestyle changes, such as reducing stress, ensuring adequate sleep, and regular physical activity, can also positively impact the gut microbiome. In cases where antibiotic use has contributed to microbial imbalance, exploring alternatives or adjuncts to antibiotic therapy with a healthcare provider may be beneficial.
In instances where an overgrowth of Clostridiales Incertae Sedis IV is linked to specific gastrointestinal conditions or symptoms, healthcare professionals may suggest additional diagnostic testing or targeted treatments. This might include personalized dietary plans, specialized probiotic supplements specifically chosen to address individual microbial imbalances, or other medical interventions based on the individual's health status and needs.
Currently, there is limited specific research directly linking Clostridiales Incertae Sedis IV, a group of gut bacteria of uncertain classification, to Parkinson's disease. However, the broader scientific community is increasingly interested in the connection between the gut microbiome and neurological conditions, including Parkinson's disease. This interest stems from the "gut-brain axis," a bidirectional communication pathway between the gastrointestinal tract and the central nervous system, which suggests that changes in the gut microbiota could potentially influence brain health and disease.
In Parkinson's disease, research has shown alterations in the composition of the gut microbiota compared to healthy individuals. These changes in gut bacteria composition might influence the disease's development or progression through various mechanisms, such as inflammation, the production of neurotoxic metabolites, or the modulation of the gut-brain axis. Bacteria in the Clostridiales order, known for their role in fermenting various substrates in the gut, could potentially impact these processes. However, the specific role of Clostridiales Incertae Sedis IV in Parkinson's disease has not been distinctly identified or studied.
As research in this area is still evolving, it's crucial to approach any potential links between specific groups of gut bacteria, like Clostridiales Incertae Sedis IV, and Parkinson's disease with caution. Future studies are needed to unravel the complexities of the gut-brain axis and the precise role of various gut bacteria, including Clostridiales Incertae Sedis IV, in neurological conditions like Parkinson's disease. Such research could open new avenues for understanding the pathogenesis of Parkinson's disease and potentially lead to novel therapeutic strategies targeting the gut microbiome.
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Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.
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Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
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If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
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View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
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After collecting lab results from different providers, you can download your entire history combined into a single file.
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Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
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There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
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