Collinsella is a genus of bacteria commonly found in the human gut and plays a role in breaking down carbohydrates and producing certain metabolites. While present in healthy individuals, Collinsella becomes clinically relevant when it grows in excess. Research shows that elevated Collinsella is associated with increased intestinal permeability, higher inflammatory markers, insulin resistance, metabolic syndrome, obesity, and cardiovascular risk factors.
High Collinsella abundance is also linked to reduced butyrate-producing bacteria and higher production of pro-inflammatory metabolites, which can weaken the gut barrier and contribute to systemic inflammation. Patients with rheumatoid arthritis and certain autoimmune conditions also tend to show elevated levels, suggesting a role in immune dysregulation.
Low levels are generally not concerning and may indicate a balanced microbiome or dietary patterns lower in fermentable carbohydrates.
On the Gut Zoomer panel, Collinsella helps identify patterns related to inflammation, metabolic health, carbohydrate fermentation, and gut barrier integrity, making it a meaningful marker for both digestive and whole-body health.
Collinsella
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