Other names: Cortisol, 30 Min
Cortisol, 30 minutes post-injection refers to the level of cortisol in your blood measured 30 minutes after receiving an injection of synthetic ACTH (Cosyntropin) during the ACTH stimulation test. This marker helps assess how well your adrenal glands respond to stimulation and is critical in diagnosing conditions like adrenal insufficiency and pituitary dysfunction.
This 30-minute cortisol value reflects your adrenal glands’ immediate response to ACTH, which normally triggers the adrenal cortex to produce and release cortisol. In a healthy response, cortisol levels should rise significantly from the baseline (pre-injection) level within 30 minutes. The degree of increase helps determine whether the adrenal glands are functioning properly and whether the hypothalamic-pituitary-adrenal (HPA) axis is intact.
A normal cortisol response at 30 minutes is typically ≥18 µg/dL, though some labs may accept values as slightly lower depending on the baseline.
A blunted or minimal rise in cortisol at 30 minutes can indicate a problem with adrenal function or ACTH signaling.
Primary adrenal insufficiency (Addison’s disease) – the adrenal glands are damaged and can't respond to ACTH
Secondary adrenal insufficiency – due to pituitary dysfunction or long-term corticosteroid use suppressing ACTH production
Recent adrenal suppression – such as from stopping steroid medications
Suggests that the adrenal glands are responsive and functioning normally
Helps rule out adrenal insufficiency when combined with baseline and 60-minute results
Sample type: Serum
Tube type: Serum separator tube (gold-top or tiger-top)
Timing: Drawn exactly 30 minutes after Cosyntropin injection for accurate interpretation
This marker is part of a three-point evaluation (baseline, 30 minutes, 60 minutes) in the Cosyntropin stimulation test, used to:
Diagnose adrenal insufficiency
Evaluate pituitary or hypothalamic dysfunction
Monitor adrenal recovery in patients previously on corticosteroids
Cortisol, 30 minutes post-injection is a key indicator of how effectively your adrenal glands respond to ACTH stimulation. A healthy increase in cortisol at this time point supports normal adrenal function, while a poor response may point to adrenal or pituitary disorders. This measurement, alongside baseline and 60-minute cortisol values, gives clinicians essential insight into your endocrine health and helps guide further diagnostic or treatment decisions.
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Cortisol, 30 minutes post-injection measures the adrenal glands' immediate response to synthetic ACTH (Cosyntropin) and is a critical marker in diagnosing adrenal insufficiency. Traditionally, a cortisol level of ≥18 µg/dL at this time point has been considered a normal response, especially when older immunoassays were used. Levels below 18 µg/dL may indicate an inadequate adrenal response, raising concern for conditions like primary adrenal insufficiency (Addison’s disease) or secondary adrenal insufficiency due to pituitary dysfunction or recent corticosteroid use. However, more recent guidelines and newer, more specific assays such as LC-MS/MS suggest slightly lower cutoffs may be acceptable—around 14.6 to 15 µg/dL. In healthy individuals, the median 30-minute cortisol response typically falls near 21.7 µg/dL, with a reference range from 15.7 to 29.1 µg/dL. Because cortisol assays and thresholds vary by lab, it’s essential to interpret results within the context of the lab’s specific reference range and the patient’s clinical picture. Persistently low cortisol responses at 30 minutes may warrant further endocrine evaluation to determine the root cause of adrenal or pituitary dysfunction.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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