Docosahexaenoic (DHA) 22:6 n3

check icon Optimal Result: 0.8 - 5 wt %.

Docosahexaenoic acid (DHA) is an omega-3 fatty acid with 22 carbons and 6 double bonds (22:6n3). It can be obtained from the diet, supplemented, or created by conversion from DPA using elongase and desaturase enzymes. DHA is present in fatty fish such as salmon, tuna, and mackerel, and low levels of DHA can be found in meat and eggs. Both individually or in combination with EPA, DHA is widely supplemented due to the enormous amount of research available regarding its anti-inflammatory role in many clinical conditions such as cardiovascular disease, cognitive decline, autoimmune disease, fetal development, visual disturbances, cancer, and metabolic syndrome.

References:

- Swanson D, Block R, Mousa SA. Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life. Advances in Nutrition. 2012;3(1):1-7.

- Richardson AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. International review of psychiatry. 2006;18(2):155-172.

- Riediger ND, Othman RA, Suh M, Moghadasian MH. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc. 2009;109(4):668-679.

- Horrocks LA, Yeo YK. Health benefits of docosahexaenoic acid (DHA). Pharmacological research. 1999;40(3):211-225.

- Chapkin RS, Kim W, Lupton JR, McMurray DN. Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. Prostaglandins Leukot Essent Fatty Acids. 2009;81(2-3):187-191.

- Kuda O. Bioactive metabolites of docosahexaenoic acid. Biochimie. 2017;136:12-20.

- Nelson GJ, Schmidt PS, Bartolini GL, Kelley DS, Kyle D. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids. 1997;32(11):1129-1136.

What does it mean if your Docosahexaenoic (DHA) 22:6 n3 result is too high?

Elevations in DHA can be seen in high omega-3 dietary intake and in patients who are supplementing with fish oil. In addition to the clinical implications outlined above, having adequate levels of DHA is important for neuroprotection, blood pressure regulation, protection from cardiac arrythmia, inflammation, and tumorigenesis. Much like EPA, oversupplementation with DHA was initially thought to increase bleeding, especially in patients also taking anticoagulants. However, literature is showing that fish oil containing EPA and DHA does not increase perioperative bleeding in patients undergoing invasive procedures. In fact, higher levels are associated with lower risk of bleeding in these patients.

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