Immunoglobulin G (IgG) is the most abundant type of antibody in your blood and body fluids. It plays a central role in your immune system’s defense against infections, especially bacterial and viral pathogens.
IgG antibodies are produced by B cells in response to foreign invaders. Once produced, they help neutralize pathogens, trigger other immune cells to attack, and form long-term immune memory—which is the basis of how vaccines work.
The “RDL” in the test name refers to Rheumatology Diagnostics Laboratory, a specialized lab that often analyzes autoimmune and immunologic markers.
An IgG blood test helps evaluate how well your immune system is functioning. It may be ordered to investigate:
Frequent or severe infections (suggesting immunodeficiency)
Autoimmune conditions (suggesting overactivity or dysregulation)
Chronic inflammation
Monoclonal gammopathies or plasma cell disorders (e.g., multiple myeloma)
Monitoring after immunoglobulin therapy or bone marrow transplant
It’s also commonly measured alongside IgA and IgM as part of a quantitative immunoglobulin panel.
An elevated IgG level can indicate that your immune system is overactive or responding to chronic infection, inflammation, or autoimmune disease.
Common causes of elevated IgG include:
Tuberculosis
Chronic hepatitis (especially hepatitis B or C)
HIV/AIDS (in some phases)
Fungal or parasitic infections
Lupus (SLE)
Rheumatoid arthritis
Autoimmune hepatitis
Sarcoidosis
Chronic allergic conditions
Inflammatory bowel disease (IBD)
Chronic lung or liver disease
Multiple myeloma or MGUS (monoclonal gammopathy of undetermined significance)
In these cases, IgG may be elevated due to uncontrolled production by abnormal plasma cells.
A low IgG level may suggest that your immune system can’t produce enough antibodies, leaving you vulnerable to infections.
Possible causes of low IgG include:
Common Variable Immunodeficiency (CVID)
X-linked agammaglobulinemia
Selective IgG subclass deficiency
Chronic lymphocytic leukemia (CLL)
Immunosuppressive therapies (e.g., chemotherapy, corticosteroids)
Nephrotic syndrome (IgG lost in urine)
Protein-losing enteropathy
Bone marrow failure or transplant
People with low IgG often have frequent respiratory infections, chronic sinusitis, or pneumonia and may require immunoglobulin replacement therapy (IVIG or SCIG).
A normal IgG level suggests your immune system is producing antibodies appropriately and there’s no current evidence of a major immune deficiency or hyperactivity.
However, normal levels don’t always rule out disease—clinical symptoms and other lab findings are essential to the full picture.
If IgG is elevated:
Your doctor may order additional testing, such as:
IgA, IgM, and IgE levels
Autoimmune panels (ANA, RF, dsDNA)
Protein electrophoresis (SPEP/UPEP) to detect monoclonal spikes
Infectious disease screening
You may be referred to a rheumatologist, infectious disease specialist, or hematologist
If IgG is low:
Your provider may:
Order IgG subclass testing
Evaluate your infection history
Consider immunoglobulin replacement therapy if infections are frequent
Refer you to an immunologist
IgG (Immunoglobulin G) is a vital part of your immune defense system. Abnormal levels—either too high or too low—can be a sign of chronic infection, autoimmune activity, immune deficiency, or other systemic conditions. Whether you're experiencing frequent infections or unexplained inflammation, this test offers critical insight into how your immune system is functioning and what steps may be needed next.
Your medical lab tests hold vital information about your health. Our tools help you understand what's going on and how to take action.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Healthmatters is a highly-personalized health dashboard.
Instead of searching for your lab results in different places or tracking them down from different providers, Healthmatters houses, organizes, and interprets them all in one central location.
With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.
For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.
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You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you’re on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
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Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
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Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
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We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
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Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
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Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
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