Other names: LEUKOTRIENE E4, RANDOM, U
Optimal Result:
0 - 104 pg/mg Cr.
Leukotriene E4 (LTE4) is a vital component in the family of leukotrienes, which play a crucial role in the body's inflammatory response.
Leukotrienes are chemicals your body releases (for example, when you come into contact with something you're allergic to).
As a part of the eicosanoid family, LTE4 is primarily known for its involvement in asthma and allergic reactions, making it a significant target for medical research and treatment strategies.
How is Leukotriene E4 (LTE4) formed?
The synthesis of leukotrienes, including LTE4, occurs through the metabolism of arachidonic acid, which is a type of fatty acid found in the cell membranes. LTE4 specifically is formed from the sequential conversion of leukotriene A4 (LTA4) to leukotriene C4 (LTC4), and then to leukotriene D4 (LTD4), before finally becoming LTE4.
→ This process highlights the intricate biochemical pathways involved in inflammation and immune response.
In the context of asthma and allergies, LTE4 has been identified as a key mediator. It contributes to a range of symptoms such as:
→ bronchoconstriction,
→ increased mucus secretion,
→ and enhanced vascular permeability,
which are hallmark features of these conditions.
This has led to the development of various pharmaceutical agents aimed at blocking the effects of LTE4 and other leukotrienes, providing relief for individuals suffering from these chronic conditions.
Research into LTE4 has also extended into other areas of health, including its role in cardiovascular diseases and certain types of cancer. Studies are exploring how LTE4’s involvement in inflammatory pathways might influence the development and progression of these diseases, offering new perspectives on treatment and prevention strategies.
In summary, Leukotriene E4 is a critical molecule in the field of immunology and inflammation. Its role in asthma, allergies, and potentially in other serious health conditions, underscores the importance of ongoing research in this area. Understanding the mechanisms of LTE4 not only contributes to better management of inflammatory diseases but also opens avenues for new therapeutic interventions in a variety of health disorders.
Referenced studies/papers:
→ A study discussing the functionality of Leukotriene E4 as a full agonist for human cysteinyl leukotriene type 1 receptor-dependent gene expression. This research highlights the significant role of Leukotriene E4 in cellular processes related to gene expression and its potential implications in health and disease [L].
Foster HR, Fuerst E, Branchett W, Lee TH, Cousins DJ, Woszczek G. Leukotriene E4 is a full functional agonist for human cysteinyl leukotriene type 1 receptor-dependent gene expression. Sci Rep. 2016 Feb 2;6:20461. doi: 10.1038/srep20461. PMID: 26830450; PMCID: PMC4735867.
→ An investigation into the role of urinary Leukotriene E4 as a biomarker in chronic rhinosinusitis, aspirin-exacerbated respiratory disease, and asthma. This comprehensive review emphasizes the diagnostic and prognostic value of Leukotriene E4 in these conditions [L].
Choby G, Low CM, Levy JM, Stokken JK, Pinheiro-Neto C, Bartemes K, Marino M, Han JK, Divekar R, O'Brien EK, Lal D. Urine Leukotriene E4: Implications as a Biomarker in Chronic Rhinosinusitis. Otolaryngol Head Neck Surg. 2022 Feb;166(2):224-232. doi: 10.1177/01945998211011060. Epub 2021 May 11. PMID: 33973823.
→ A perspective on Leukotriene E4 as a 'forgotten' mediator, detailing its involvement in various physiological and pathological processes, particularly in the context of bronchial asthma and related conditions [L].
Lee TH, Woszczek G, Farooque SP. Leukotriene E4: perspective on the forgotten mediator. J Allergy Clin Immunol. 2009 Sep;124(3):417-21. doi: 10.1016/j.jaci.2009.04.020. Epub 2009 May 30. PMID: 19482346.
→ Research that associates elevated urine Leukotriene E4 levels with worse objective markers in nasal polyposis patients. This study contributes to the understanding of the role of Leukotriene E4 in nasal polyps and potentially its utility in disease management [L].
Choby G, O'Brien EK, Smith A, Barnes J, Hagan J, Stokken JK, Strumpf A, Mattos JL, Payne SC, Divekar R. Elevated Urine Leukotriene E4 Is Associated With Worse Objective Markers in Nasal Polyposis Patients. Laryngoscope. 2021 May;131(5):961-966. doi: 10.1002/lary.29137. Epub 2020 Oct 1. PMID: 33001452.
→ A systematic review and meta-analysis focusing on urinary Leukotriene E4 as a biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD). This comprehensive analysis provides insights into the diagnostic and predictive capabilities of Leukotriene E4 in this specific context [L].
Marquette M, Tailor BV, Calder PC, Curtis PJ, Loke Y, Wilson AM. Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis. Curr Allergy Asthma Rep. 2022 Dec;22(12):209-229. doi: 10.1007/s11882-022-01049-8. Epub 2022 Nov 14. PMID: 36374376; PMCID: PMC9732072.
An elevated level of Leukotriene E4 (LTE4), particularly in a random urine sample (Random, U), is indicative of heightened leukotriene activity in the body. Leukotrienes are chemicals that play a significant role in the inflammatory process, especially in the lungs. An increase in LTE4 is often associated with inflammatory respiratory diseases such as asthma, allergic rhinitis (inflammation of the inside of the nose caused by an allergen), chronic rhinosinusitis (long-term inflammation of nasal and sinus tissues), nasal polyps (painless, noncancerous growths in nasal passages), and aspirin-exacerbated respiratory disease (AERD). Aspirin-Exacerbated Respiratory Disease (AERD) is a chronic condition characterized by asthma, nasal polyps, and sensitivity to aspirin and other NSAIDs.
Diagnosis: Elevated LTE4 levels can be particularly useful in diagnosing these conditions. For example, in the context of asthma, increased LTE4 might suggest a more severe or uncontrolled form of the disease. Similarly, in chronic rhinosinusitis, higher LTE4 levels can be indicative of a more severe inflammatory response. In cases of AERD, elevated LTE4 can be a marker for the disease and help in distinguishing it from other forms of respiratory conditions.
Symptoms: The symptoms associated with conditions linked to high LTE4 levels can vary but often include respiratory difficulties such as wheezing, shortness of breath, nasal congestion, and sinus pain. In asthma, this might manifest as more frequent and severe asthma attacks. In chronic rhinosinusitis and nasal polyps, symptoms can include persistent nasal blockage, loss of smell, and facial pain.
Potential Treatment Plans: Treatment for conditions associated with elevated LTE4 often involves managing inflammation and alleviating symptoms. In asthma, this may include the use of inhaled corticosteroids, bronchodilators, and leukotriene receptor antagonists like montelukast. For chronic rhinosinusitis and nasal polyps, treatment might involve nasal corticosteroids, saline nasal irrigation, and in severe cases, surgery. In AERD, management includes avoiding aspirin and NSAIDs, and treatments may involve aspirin desensitization under medical supervision.
It is important to note that the interpretation of elevated LTE4 levels should be done in conjunction with clinical symptoms and other diagnostic tools. The management of these conditions is often multifaceted, involving both pharmacological and non-pharmacological strategies. Close monitoring and regular follow-up with healthcare providers are crucial for effective disease management.
For more detailed information on the implications of elevated Leukotriene E4, symptoms, diagnosis, and treatment plans, consulting specific medical resources or healthcare professionals is recommended.
-----------------------
Referenced studies/papers:
→ Chronic Rhinosinusitis, Asthma, and AERD: A comprehensive review emphasized the role of urinary LTE4 as a biomarker in chronic rhinosinusitis (CRS), aspirin-exacerbated respiratory disease (AERD), and asthma. It highlighted its utility in diagnosing these conditions and predicting their severity [L].
Choby G, Low CM, Levy JM, Stokken JK, Pinheiro-Neto C, Bartemes K, Marino M, Han JK, Divekar R, O'Brien EK, Lal D. Urine Leukotriene E4: Implications as a Biomarker in Chronic Rhinosinusitis. Otolaryngol Head Neck Surg. 2022 Feb;166(2):224-232. doi: 10.1177/01945998211011060. Epub 2021 May 11. PMID: 33973823.
→ NSAID-Induced Reactions: In a study focused on NSAID-induced blended reactions (NIBR) and NSAID-exacerbated respiratory disease (NERD), it was found that LTE4 levels were significantly elevated after aspirin provocation in patients with these conditions. This suggests that increased LTE4 levels can indicate NSAID cross-reactivity with respiratory components [L].
Klaewsongkram J, Buranapraditkun S, Mongkolpathumrat P, Palapinyo S, Chantaphakul H. Clinical Characteristics, Urinary Leukotriene E4 Levels, and Aspirin Desensitization Results in Patients With NSAID-Induced Blended Reactions. Allergy Asthma Immunol Res. 2021 Mar;13(2):229-244. doi: 10.4168/aair.2021.13.2.229. PMID: 33474858; PMCID: PMC7840864.
Nasal Polyposis: Research has shown that elevated urine LTE4 levels are associated with worse objective markers in nasal polyposis patients. This indicates that LTE4 can be a valuable marker for assessing the severity of this condition [L].
Choby G, O'Brien EK, Smith A, Barnes J, Hagan J, Stokken JK, Strumpf A, Mattos JL, Payne SC, Divekar R. Elevated Urine Leukotriene E4 Is Associated With Worse Objective Markers in Nasal Polyposis Patients. Laryngoscope. 2021 May;131(5):961-966. doi: 10.1002/lary.29137. Epub 2020 Oct 1. PMID: 33001452.
Diagnostic Utility: Another study explored the diagnostic utility of urinary LTE4 in asthma, allergic rhinitis, chronic rhinosinusitis, nasal polyps, and aspirin sensitivity, underscoring its broad applicability in various allergic and respiratory conditions [L].
Divekar R, Hagan J, Rank M, Park M, Volcheck G, O'Brien E, Meeusen J, Kita H, Butterfield J. Diagnostic Utility of Urinary LTE4 in Asthma, Allergic Rhinitis, Chronic Rhinosinusitis, Nasal Polyps, and Aspirin Sensitivity. J Allergy Clin Immunol Pract. 2016 Jul-Aug;4(4):665-70. doi: 10.1016/j.jaip.2016.03.004. Epub 2016 Apr 12. PMID: 27080204; PMCID: PMC5103699.
Treatment Plans: Regarding treatment, antileukotriene therapy has been recognized for its potential in managing asthma and allergic diseases. The role of leukotriene E4 in these conditions necessitates a clear understanding of how antileukotrienes can be effectively used in clinical practice [L].
Scadding GW, Scadding GK. Recent advances in antileukotriene therapy. Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):370-6. doi: 10.1097/ACI.0b013e32833bfa20. PMID: 20585242.
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If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
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See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
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After collecting lab results from different providers, you can download your entire history combined into a single file.
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
With a Healthmatters account, you can:
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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