Neutrophils (Percent)

Other names: % Neutrophil, POLYS, ABS. COUNT, POLYS, Neutrophils %

check icon Optimal Result: 50 - 70 %.

What Are Neutrophils?

Neutrophils are the most abundant type of white blood cell (WBC) in your body, making them a vital component of your immune system. Produced in the bone marrow, these specialized cells travel through the bloodstream to detect and fight infections, as well as assist in healing damaged tissues. Their ability to respond rapidly to infections or injuries makes them your body’s first line of defense against harmful invaders such as bacteria and viruses.

How Do Neutrophils Work?

Neutrophils are phagocytic cells, meaning they engulf and destroy harmful microorganisms at the site of an infection or injury. Once they identify pathogens, neutrophils trap and digest these invaders. They also release enzymes that trigger inflammation, which is why swelling, redness, or warmth often occurs when your body is fighting off an infection.

Despite their critical role, neutrophils have a short lifespan of less than 24 hours. To maintain their numbers, your bone marrow constantly produces new neutrophils, ensuring a continuous supply to protect your body.

Neutrophils and Leukocytes: Understanding Their Relationship

Neutrophils are a subset of leukocytes, also known as white blood cells. While white blood cells make up only 1% of your total cells, they are indispensable for immune health. Among the various types of leukocytes, neutrophils are the most prevalent, accounting for 50-80% of the total.

Leukocytes are broadly categorized into three main groups:

  1. Granulocytes: Includes neutrophils, eosinophils, and basophils.
  2. Lymphocytes: Includes T-cells, B-cells, and natural killer cells.
  3. Monocytes: Become macrophages and aid in tissue repair.

Each type of leukocyte plays a specific role in protecting your body, with neutrophils serving as the frontline defenders against infections.

Why Is Monitoring Neutrophil Count Important?

Measuring your neutrophil count provides critical insights into your immune health. A standard test called the Absolute Neutrophil Count (ANC) measures the number of neutrophils in your blood. The normal ANC range for adults is 2,500–6,000 neutrophils per microliter of blood. Deviations from this range may indicate underlying health issues:

  • Low Neutrophil Count (Neutropenia): Counts below 2,500 may suggest conditions such as leukemia, vitamin B12 deficiency, or the effects of chemotherapy.
  • High Neutrophil Count (Neutrophilia): Counts above 6,000 are often associated with infections, inflammation, stress, or even certain types of leukemia.

Regular monitoring of your neutrophil count helps your healthcare provider assess the overall state of your immune system and detect potential health problems early.

Neutrophils in Action: The Immune Response

When an infection or injury occurs, neutrophils are the first immune cells to arrive at the scene. They act quickly to neutralize harmful bacteria and pathogens through a process called phagocytosis, where they trap, ingest, and digest the invaders. In addition to direct pathogen destruction, neutrophils release chemical signals that recruit other immune cells, amplifying the body’s immune response.

This rapid and coordinated response is crucial in preventing the spread of infection and promoting tissue repair.

Conclusion

Neutrophils are an essential part of your immune system, serving as your body’s frontline defenders against infection and injury. Understanding the importance of these cells and monitoring your neutrophil count through regular blood tests can help detect immune-related issues early. Whether it’s fighting off bacteria, aiding in tissue healing, or signaling other immune cells, neutrophils play a central role in maintaining your overall health.


References

  • American Cancer Society. Low white blood cell (neutrophil) counts and the risk of infection.
  • National Cancer Institute. Absolute neutrophil count.
  • Centers for Disease Control and Prevention. What you need to know: neutropenia and risk for infection.
  • Merz LE et al. Absolute neutrophil count by Duffy status among healthy Black and African American adults. Blood Adv. 2023 Feb;7(3):317-320. doi:10.1182/bloodadvances.2022007679.
  • American Society of Hematology. How we evaluate and treat neutropenia in adults.

What does it mean if your Neutrophils (Percent) result is too high?

What Is Neutrophilia?

Neutrophilia refers to an elevated number of neutrophils, a type of white blood cell, as detected on a complete blood count (CBC) test. Neutrophils play a key role in your immune system by fighting infections and responding to inflammation. An increased neutrophil count can occur due to various physiological, pathological, and environmental factors.


Types of Neutrophilia

Shift Neutrophilia

Shift neutrophilia is typically transient and occurs when neutrophils move from the marginal pool (lining blood vessel walls) into the circulating blood. It is commonly triggered by:

  • Vigorous exercise
  • Epinephrine injections
  • Seizures
  • Paroxysmal tachycardia

This type of neutrophilia usually lasts only 20-30 minutes and does not involve an increased production of neutrophils from the bone marrow.

True Neutrophilia

True neutrophilia involves an actual increase in neutrophil production by the bone marrow, often in response to infections or inflammation. During early infections, neutrophil counts may temporarily drop as cells migrate to the site of infection.


Causes of Neutrophilia

Infectious Causes

Acute infections caused by various pathogens can lead to neutrophilia. Examples include:

  • Bacteria: Staphylococci, Streptococci, Escherichia coli, Pseudomonas aeruginosa
  • Fungi: Candida albicans, Coccidioides immitis
  • Viruses: Herpes zoster, rabies, poliomyelitis
  • Parasites: Liver fluke

Neutrophilia is also commonly seen in conditions such as:

  • Appendicitis
  • Tonsillitis
  • Otitis media
  • Osteomyelitis
  • Peritonitis

However, certain infections like typhoid fever, tuberculosis, mumps, and measles typically do not cause neutrophilia.

Non-Infectious Causes

Non-infectious conditions that can result in neutrophilia include:

  • Burns
  • Postoperative recovery (12-36 hours post-surgery)
  • Acute asthma attacks
  • Myocardial infarction
  • Rheumatic fever
  • Hypersensitivity reactions
  • Collagen-vascular diseases
  • Acute gout attacks
  • Cigarette smoking

Neutrophilia and Inflammation

In cases like severe burns, neutrophilia is accompanied by a "shift to the left," with immature neutrophil forms (bands) and degenerative changes such as toxic granulation or Dohle bodies. During cardiopulmonary bypass surgery, neutrophil activation occurs due to interleukin-8 (IL-8) and complement system activation, contributing to inflammatory responses.


Metabolic and Toxic Causes of Neutrophilia

Metabolic and toxic triggers for neutrophilia include:

  • Conditions: Diabetic ketoacidosis, preeclampsia, uremia (with or without uremic pericarditis)
  • Toxins and Poisons: Lead, mercury, insect venoms, and certain medications (e.g., phenacetin, quinidine, turpentine)

Hematologic Causes of Neutrophilia

Neutrophilia is often associated with blood-related disorders, including:

  • Acute Hemorrhage: Leukocytosis occurs as neutrophils are mobilized in response to stress or inflammation.
  • Blood Malignancies: Chronic myelocytic leukemia (CML), polycythemia vera, myelofibrosis, and myeloid metaplasia.
  • Anemia: Seen in chronic infections or conditions like essential thrombocythemia.

Rapidly growing tumors may also cause neutrophilia due to the production of tumor necrosis factor (TNF)-alpha or granulocyte colony-stimulating factor (G-CSF).


Physiological Neutrophilia

Transient neutrophilia can occur in:

  • Strenuous exercise
  • Epinephrine injections
  • Pregnancy and labor
  • Newborns

Genetic Causes of Neutrophilia

Rare hereditary conditions can lead to chronic or persistent neutrophilia, including:

  • Hereditary Neutrophilia: Linked to activating mutations in the CSF3R gene, which regulates neutrophil production.
  • Chronic Neutrophilic Leukemia (CNL): A myeloproliferative disorder often associated with CSF3R mutations.

Other Causes of Neutrophilia

Additional triggers include:

  • Convulsions and paroxysmal tachycardia
  • Corticosteroid use
  • Cushing disease
  • Chronic idiopathic neutrophilia (persistent elevated neutrophil count without a clear cause)

Conclusion

Neutrophilia is a condition with diverse causes ranging from infections and inflammation to genetic mutations and physiological triggers. Understanding the underlying cause is essential for proper diagnosis and management. If a CBC test reveals elevated neutrophil levels, further investigation by a healthcare provider can help determine the specific cause and guide appropriate treatment.

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What does it mean if your Neutrophils (Percent) result is too low?

What Is Neutropenia?

Neutropenia is a condition characterized by an abnormally low level of neutrophils, a type of white blood cell crucial for fighting infections.

  • Severe neutropenia significantly increases the risk of life-threatening infections.
  • Neutropenia is often a side effect of cancer treatments like chemotherapy or radiation therapy.
  • Doctors may suspect neutropenia in individuals who experience frequent or unusual infections.

Without the protection provided by neutrophils, the body struggles to control infections, which can become life-threatening. When neutropenia is accompanied by fever or signs of infection, antibiotics are typically administered to manage the risk.


How Do You Test for Neutropenia?

Neutropenia is diagnosed through a blood test to measure the neutrophil count. If the cause of neutropenia is unclear, a bone marrow sample may also be required for further investigation.


What Are the Treatment Options for Neutropenia?

Treatment for neutropenia depends on its underlying cause and severity. Common treatment approaches include:

  • Medications: Drugs like colony-stimulating factors (G-CSF) are used to stimulate neutrophil production.
  • Resolving Underlying Causes: Treating infections, discontinuing medications causing neutropenia, or addressing deficiencies in vitamin B12 or folate.
  • Chronic Neutropenia: May require long-term management, as it can last for months or years.

Neutropenia Severity Classification

Neutropenia is classified based on neutrophil count levels:

  • Mild Neutropenia: 1,000 to 1,500 neutrophils/mcL (1 to 1.5 × 10x9/L).
  • Moderate Neutropenia: 500 to 1,000 neutrophils/mcL (0.5 to 1 × 10x9/L).
  • Severe Neutropenia: Fewer than 500 neutrophils/mcL (0.5 × 10x9/L).

When neutrophil counts fall below 500/mcL, the risk of infection increases significantly, and even harmless bacteria in the body may cause serious infections.


Causes of Neutropenia

Neutropenia can result from two primary mechanisms:

  1. Increased Destruction or Usage of Neutrophils:

    • Certain bacterial infections.
    • Autoimmune disorders that destroy neutrophils.
    • Enlarged spleen trapping and destroying neutrophils.
    • Allergic reactions or medications that deplete neutrophils.
  2. Decreased Neutrophil Production in Bone Marrow:

    • Cancer, radiation therapy, or viral infections like influenza.
    • Nutritional deficiencies in vitamin B12 or folate.
    • Bone marrow disorders like aplastic anemia.
    • Exposure to toxins (e.g., benzene, insecticides).
    • Certain chemotherapy or other medications.

Some rare hereditary disorders, such as cyclic neutropenia or severe congenital neutropenia, also result in low neutrophil counts.


Symptoms of Neutropenia

Neutropenia itself does not typically cause symptoms, but it makes individuals more susceptible to infections. Signs of infection include:

  • Fever and painful ulcers around the mouth or anus.
  • Severe bacterial infections like pneumonia.
  • Rash, swollen lymph nodes, and fever when neutropenia is caused by certain medications.

In cyclic neutropenia, symptoms may come and go as neutrophil levels fluctuate.


How Is Neutropenia Treated?

Treatment depends on the severity and cause of neutropenia:

  • Stop Harmful Medications or Avoid Toxins: Discontinue drugs or exposures that contribute to neutropenia.
  • Antibiotics: Administered to treat or prevent infections.
  • Growth Factors: Colony-stimulating factors (e.g., G-CSF) to boost neutrophil production.
  • Corticosteroids or Immunosuppressive Therapy: Used for autoimmune causes of neutropenia.
  • Bone Marrow Transplant: Recommended in severe cases caused by disorders like aplastic anemia or leukemia.

Infections in people with severe neutropenia can quickly become life-threatening. Immediate hospitalization and strong antibiotics are critical when fever or infection is present.


Preventing Neutropenia

While inborn types of neutropenia cannot be prevented, you can take precautions to reduce the risk of infections:

  • Wash hands frequently with soap and water or use an alcohol-based sanitizer.
  • Stay up-to-date on vaccines, including flu and COVID-19 shots.
  • Avoid contact with sick individuals or crowded areas.
  • Protect against injuries by wearing gloves during activities like gardening.
  • Practice good hygiene in food preparation and avoid raw or undercooked foods.
  • Avoid sharing personal items like towels, razors, or toothbrushes.
  • Follow your healthcare provider’s advice, including taking prescribed prophylactic medications.

For those undergoing chemotherapy, healthcare providers may delay treatment, lower the dose, or prescribe G-CSF injections to increase neutrophil levels.


Conclusion

Neutropenia is a serious condition that compromises your immune system’s ability to fight infections. Understanding the causes, symptoms, and treatment options for neutropenia is crucial for managing the condition effectively. By taking preventive measures and seeking immediate medical attention for signs of infection, individuals with neutropenia can reduce the risk of complications and improve their overall health.

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