Urinary nickel (Ni) provides an indication of recent or ongoing exposure to the metal, and endogenous detoxification to a lesser extent. There is substantial evidence that Ni is an essential trace element.
However, excessive assimilation of Ni has been established to be nephrotoxic, and carcinogenic. The general population may be exposed to Ni from ambient air, water and food. With the exception of specific occupational exposures, most absorbed Ni comes from food and beverages, and intakes can vary depending upon geographical location and water supply. Extensive Ni exposure may occur with cigarette
smoking.
Ni is present at relatively higher levels in a large number of foods and food products, including: hydrogenated oils (margarine), black tea, nuts and seeds, soy milk and chocolate milk, chocolate and cocoa powders, certain canned and processed foods, and certain grains such as oats, buckwheat, whole wheat, and wheat germ. Other sources of Ni include: urban air/particulate diesel exhaust, Ni-Cd batteries, non-
precious/ semiprecious dental materials, pigments (usually for ceramics or glass), arc welding, and nickel refining, metallurgical processes and electroplating.
Hair elemental analysis may confirm exposure to Ni over the past 2-4 months.
Chelation may acutely increase urinary excretion of Ni.
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Urinary excretion of nickel bound to cysteine or other thiol compounds (such as glutathione) or to amino acids (histidine, aspartic acid, arginine) is the predominant mode of excretion. With the exception of specific occupational exposures, most absorbed Ni comes from food or drink, and intakes can vary by factors exceeding 100 depending upon geographical location, diet, and water supply. Nickel is present in a surprisingly large number of foods and food products, including: hydrogenated oils, black tea, nuts and seeds, soy milk and chocolate milk, chocolate and cocoa powders, certaincanned and processed foods, including meat and fish, certain grains, including: oats, buckwheat, whole wheat and wheat germ. 1 to 10% of dieatry Ni may be absorbed from the gastrointestinal tract into the blood. Urine reflects recent exposure to nickel and ay vary widely in nickel content from day to day.
Other sources of Ni include cigarettes (2 to 6 mcg Ni per average cigarett), diesel exhaust, Ni-Cd batteries, nonprecious, seminprecious dental materials, electroplating, plated objects, costume jewelry and pigments (usually for ceramics or glass), Arc welding, and metallurgical processes.
Most clinically relavant Ni exposures are manifested as dermatoses - contact dermatitis and atopic dermatitis. However, Ni hypersensitizes the immune system and may cause hyperallergenic responses to many different substances. Because Ni can displace zinc from binding sites on enzymes it can affect abnormal enzymatic activity. Nickel sensitivity is observed to be three to five times more prevelant in females than in males.
Other laboratory tests or possible clinical findings that may be associated with Ni exposure are; hair elements analysis, presentation of multiple allergic sensitivities, dermatitis, positive patch test for "Ni allergy", proteinuria, hyperaminoaciduria (by 24-hour urine amino acid analysis). Administration of EDTA or sulfhydryl agents (DMPS, DMSA, D-penicillamine) may increase urine Ni levels; such chelator- induced elevations may or may not be associated with adverse health effects.
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Join the community of thousands who've transformed the way they understand their lab results. Experience the joy of having all your lab data neatly organized, regardless of where or when the tests were done.
For our professional users, Healthmatters.io is a game-changer. Revel in the intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history. It's not just a dashboard; it's your gateway to a smarter, more informed health journey!
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You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
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There are two ways to add your test reports to your healthmatters.io account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
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For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
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Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
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