Parathyroid Hormone, intact

Other names: PTH, Intact, PTH, INTACT WITHOUT CALCIUM

check icon Optimal Result: 16 - 77 pg/mL, or 1.68 - 8.11 pmol/L.

Parathyroid Hormone (PTH), Intact, plays a crucial role in maintaining a delicate balance in our body's calcium and phosphorus levels, directly impacting bone health. This hormone, produced by the parathyroid glands located behind the thyroid gland in the neck, regulates calcium levels in the blood by influencing bone remodeling, the process where old bone tissue is replaced by new. When calcium levels drop, PTH is secreted, increasing calcium absorption in the intestines, reducing its excretion by the kidneys, and stimulating the release of calcium from bones. This function is vital as calcium is essential for many bodily functions, including nerve signaling, muscle contraction, and blood clotting. An intact PTH test, a common blood test, measures the level of this hormone in your blood. It's an essential diagnostic tool, particularly for conditions like hyperparathyroidism, where the parathyroid glands produce too much PTH, or hypoparathyroidism, where they produce too little. Understanding PTH levels can help in diagnosing and managing various conditions related to bone density, kidney stones, and the body's overall calcium levels. This information is crucial for anyone seeking to maintain optimal bone health and prevent related diseases.

Interpretive Guide

Intact PTH

Calcium

Normal Parathyroid

Normal

Normal

Hypoparathyroidism

Low or Low Normal

Low

Hyperparathyroidism

  • Primary
  • Secondary
  • Tertiary

 

  • Normal/ High
  • High
  • High

 

  • High
  • Normal/ Low
  • High

Non-Parathyroid

  • Hypercalcemia

 

  • Low/ Low Normal

 

  • High

What does it mean if your Parathyroid Hormone, intact result is too high?

If your test shows you have a higher than normal level of PTH, it may mean you have:

- Hyperparathyroidism
- A benign (noncancerous) tumor of the parathyroid gland
- Kidney disease
- A vitamin D deficiency
- A disorder that makes you unable to absorb calcium from food

Symptoms of high parathyroid hormone levels:

Since parathyroid hormone (PTH) mainly controls the amount of calcium in your blood, which has several important functions, the symptoms you’ll experience from high PTH levels are actually symptoms of high blood calcium levels.

Symptoms of high blood calcium levels (hypercalcemia) include:

- Joint pain and bone pain.
- More frequent urination and thirst.
- Muscle aches, weakness, cramping and/or twitches
- Fatigue.
- Depression and/or memory loss.
- Decrease in appetite.
- Nausea and vomiting.
- Constipation.

Note: If you experience these symptoms of hypercalcemia, it’s important to contact your healthcare provider.

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Hyperparathyroidism is an excess of parathyroid hormone in the bloodstream due to overactivity of one or more of the body's four parathyroid glands. These glands are about the size of a grain of rice and are located in your neck.

The parathyroid glands produce parathyroid hormone, which helps maintain an appropriate balance of calcium in the bloodstream and in tissues that depend on calcium for proper functioning.

Two types of hyperparathyroidism exist. In primary hyperparathyroidism, an enlargement of one or more of the parathyroid glands causes overproduction of the hormone, resulting in high levels of calcium in the blood (hypercalcemia), which can cause a variety of health problems. Surgery is the most common treatment for primary hyperparathyroidism.

Secondary hyperparathyroidism occurs as a result of another disease that initially causes low levels of calcium in the body and over time, increased parathyroid hormone levels occur.

Interpretive Guide

Intact PTH

Calcium

Normal Parathyroid

Normal

Normal

Hypoparathyroidism

Low or Low Normal

Low

Hyperparathyroidism

  • Primary
  • Secondary
  • Tertiary

 

  • Normal/ High
  • High
  • High

 

  • High
  • Normal/ Low
  • High

Non-Parathyroid

  • Hypercalcemia

 

  • Low/ Low Normal

 

  • High

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What does it mean if your Parathyroid Hormone, intact result is too low?

Low levels of Parathyroid Hormone (PTH) can lead to a condition called hypoparathyroidism. This typically happens when the parathyroid glands do not produce enough PTH, affecting the balance of calcium and phosphorus in the body. Common causes include accidental damage or removal of the parathyroid glands during thyroid surgery, autoimmune diseases, or a genetic component. Symptoms of low PTH include muscle cramps or spasms, tingling in the fingertips, toes, and lips, and general fatigue. These symptoms are mainly due to low calcium levels in the blood. Treatment focuses on maintaining normal calcium and phosphorus levels, often involving calcium and vitamin D supplements to compensate for the reduced PTH. In some cases, hormone replacement therapy might be recommended. Regular monitoring and consultation with a healthcare provider are crucial for managing this condition effectively.

Interpretive Guide

Intact PTH

Calcium

Normal Parathyroid

Normal

Normal

Hypoparathyroidism

Low or Low Normal

Low

Hyperparathyroidism

  • Primary
  • Secondary
  • Tertiary

 

  • Normal/ High
  • High
  • High

 

  • High
  • Normal/ Low
  • High

Non-Parathyroid

  • Hypercalcemia

 

  • Low/ Low Normal

 

  • High

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