Pregnenolone Sulfate
Optimal Result:
1 - 23 pg/mL.
Pregnenolone sulfate is a neurosteroid that enhances the glutamate N-methyl-D-aspartate (NMDA)-receptor function and inhibits receptors for glycine, GABA, thereby regulating the excitation-inhibition balance in the CNS.
It enhances learning and memory and promotes nerve cell survival. Along with other endogenous neurosteroids, it has been implicated in the development of neuropsychiatric disorders such as schizophrenia, depression, and anxiety. Trials of the therapeutic use of pregnenolone, the precursor of pregnenolone sulfate, in schizophrenia have shown some success. Low plasma levels of pregnenolone sulfate have been observed in people with generalized social phobia.
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What does it mean if your Pregnenolone Sulfate result is too high?
Pregnenolone Sulfate is higher than reference range with topical pregnenolone therapy. Pregnenolone is sulfated to help stabilize it in the bloodstream. In tissues such as the adrenal glands, gonads, liver, and brain sulfatase cleaves the sulfate from pregnenolone sulfate to yield pregnenolone, which serves as a precursor to progesterone and 17-OH pregnenolone. Progesterone is a precursor for aldosterone and 17-OH pregnenolone serves as a precursor to DHEA and 17-OH-progesterone. DHEA is pivotal substrate for androgens and estrogens; 17-OH progesterone is a precursor substrate for cortisol.
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What does it mean if your Pregnenolone Sulfate result is too low?
Low plasma levels of pregnenolone sulfate have been observed in people with generalized social phobia.
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