The Scallop (F338) IgE test measures your immune system’s sensitivity to proteins found in scallops — a type of shellfish belonging to the mollusk family. This test specifically detects immunoglobulin E (IgE) antibodies that your body may produce in response to scallop allergens.
When someone with a scallop allergy eats scallops (or sometimes even comes into contact with them through cooking vapors or cross-contaminated utensils), their immune system can mistakenly identify scallop proteins as harmful. This triggers an IgE-mediated allergic reaction, releasing histamine and other chemicals that cause allergy symptoms.
Scallop allergy is a relatively common shellfish allergy, especially in adults. It often occurs alongside allergies to other mollusks (like clams, oysters, and mussels) or crustaceans (like shrimp, crab, and lobster).
This test helps:
Identify whether your allergic symptoms are related to scallop consumption.
Distinguish between mollusk and crustacean allergies.
Guide dietary recommendations and safety measures for people with suspected shellfish allergies.
Monitor changes in IgE levels over time to assess if sensitivity is increasing, stable, or improving.
1. Elevated Scallop (F338) IgE:
A higher-than-normal level of scallop-specific IgE suggests sensitization to scallop proteins. This means your immune system has developed antibodies that recognize scallop as a potential threat.
However, sensitization does not always mean you will have symptoms when exposed — it indicates a risk of allergic reaction.
If you experience symptoms such as:
Hives, itching, or swelling (especially around the mouth or face)
Nausea, vomiting, or abdominal pain
Wheezing, coughing, or shortness of breath
Dizziness or anaphylaxis (in severe cases)
…then elevated Scallop IgE levels likely confirm a true scallop allergy. Avoidance of scallops and possibly all mollusks is typically recommended.
2. Normal or Undetectable Scallop (F338) IgE:
Low or undetectable IgE levels suggest that you’re unlikely to have an IgE-mediated scallop allergy. However, non-IgE-mediated reactions or food intolerances (which do not involve the immune system) can still occur and cause digestive discomfort or delayed symptoms.
Scallop allergy often overlaps with other shellfish sensitivities due to shared allergenic proteins such as tropomyosin, arginine kinase, and myosin light chain.
Cross-reactivity means that if you’re allergic to scallops, you might also react to:
Clams
Mussels
Oysters
Snails
Squid
Octopus
And in some cases, to crustaceans like shrimp or lobster.
Allergy testing for multiple shellfish species can help clarify your specific sensitivities.
Strict avoidance of scallops and other related shellfish is the main treatment.
Read ingredient labels carefully — scallops can appear in mixed seafood dishes, soups, sauces, and restaurant-prepared meals.
Inform restaurants and food handlers about your allergy to prevent cross-contamination.
Carry an epinephrine auto-injector (EpiPen) if you’ve had moderate to severe reactions.
Work with an allergist to confirm your results through clinical evaluation or an oral food challenge if necessary.
Scallop (F338) IgE testing is often performed using ImmunoCAP or similar technologies that quantify allergen-specific IgE antibodies in kilounits per liter (kU/L).
Results should always be interpreted alongside clinical history, symptom presentation, and other shellfish-specific IgE results.
If multiple shellfish markers are elevated, your healthcare provider may recommend a comprehensive shellfish avoidance plan and possible nutritional guidance to compensate for lost dietary protein or minerals.
A positive Scallop (F338) IgE result indicates that your immune system recognizes scallop proteins as allergens, suggesting a risk for allergic reactions upon exposure. Because shellfish allergies can be lifelong and sometimes severe, accurate diagnosis, avoidance strategies, and emergency preparedness are essential for safety and long-term health.
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An elevated Scallop (F338) IgE level indicates that your immune system has produced a higher-than-normal amount of immunoglobulin E (IgE) antibodies that specifically target proteins found in scallops. This response suggests sensitization or allergy to scallop — a type of shellfish in the mollusk family.
When scallop proteins enter the body, a sensitized immune system recognizes them as harmful and releases inflammatory chemicals such as histamine, triggering allergy symptoms that can range from mild to severe.
Reactions can occur within minutes to hours after eating scallops or foods contaminated with scallop proteins. Common symptoms include:
Itching or tingling in the mouth
Hives, skin redness, or swelling (especially of the lips, eyes, or face)
Nausea, vomiting, or abdominal cramping
Coughing, wheezing, or shortness of breath
Dizziness, low blood pressure, or loss of consciousness (in severe cases)
In rare but serious instances, scallop allergy can lead to anaphylaxis, a life-threatening reaction that requires immediate emergency care and the use of epinephrine (EpiPen).
Scallop allergy is part of the mollusk shellfish group, which also includes clams, oysters, mussels, squid, and octopus.
Many individuals with an elevated Scallop (F338) IgE level may also react to other types of shellfish — including crustaceans (like shrimp, crab, and lobster) — because they share similar allergenic proteins such as tropomyosin.
If your scallop IgE is elevated, your healthcare provider may recommend testing for additional shellfish allergens to better understand your risk of cross-reactivity.
Even trace amounts of scallop protein can cause reactions in highly sensitive individuals.
Hidden sources may include:
Mixed seafood dishes (paella, seafood soups, chowders)
Sauces or broths made with shellfish stock
Cross-contamination in restaurant kitchens or seafood markets
Frying oils shared with other shellfish products
Reading ingredient labels and communicating your allergy clearly when dining out are key preventive steps.
Avoid all scallops and related mollusks unless otherwise advised by your allergist.
Inform food handlers and restaurants about your shellfish allergy to prevent accidental exposure.
Carry prescribed emergency medication, such as an epinephrine auto-injector, if you have a history of allergic reactions.
Consult an allergist for a full evaluation — including possible oral food challenges or testing for other shellfish allergens.
Monitor your IgE levels periodically to track changes in sensitivity over time.
While elevated IgE indicates an immune response, it does not always confirm the presence of clinical allergy symptoms. Some individuals may test positive for scallop IgE but tolerate small amounts of scallop without issue.
That’s why lab results should always be interpreted in context with your medical history and reaction patterns under the guidance of an allergist or immunologist.
An elevated Scallop (F338) IgE result means your immune system is sensitized to scallop proteins and may trigger an allergic reaction upon exposure. Because shellfish allergies are among the most common and potentially severe food allergies, strict avoidance, clear labeling awareness, and emergency preparedness are vital for staying safe.
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Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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