(Von Willebrand Factor Glycoprotein Ib-Mutant Activity)
VWF GPIbM Activity is a specialized test that measures the functional activity of von Willebrand factor (VWF) — a protein essential for normal blood clotting. This assay assesses how well VWF can bind to platelets, a key step in the formation of a blood clot to stop bleeding.
The test uses a mutant form of platelet receptor GPIbα (glycoprotein Ib alpha) to detect VWF activity, which makes it more stable, sensitive, and specific than older tests like the ristocetin cofactor assay (VWF:RCo).
VWF GPIbM Activity is used primarily in the diagnosis and classification of von Willebrand disease (VWD), the most common inherited bleeding disorder.
Von Willebrand factor (VWF) is a large multimeric protein made by endothelial cells and megakaryocytes. It has two main jobs:
Binding to collagen at sites of blood vessel injury
Binding to platelets via the GPIbα receptor, helping them stick together to form a clot
The interaction between VWF and GPIbα is crucial for primary hemostasis (the first step in stopping bleeding). When VWF can’t bind properly to platelets, bleeding may become prolonged or excessive.
This test evaluates the ability of VWF in your blood to bind to the GPIbα receptor. The “M” in GPIbM stands for mutant, indicating that the test uses a recombinant (lab-engineered) form of the GPIb receptor that binds VWF without the need for ristocetin, an antibiotic previously used in older assays.
Compared to the traditional VWF:RCo test, the VWF GPIbM assay offers:
Better precision and reproducibility
Less sensitivity to pre-analytical variables
No interference from ristocetin cofactor variability
More accurate diagnosis of von Willebrand disease, especially type 2 variants
VWF GPIbM Activity is used to:
Diagnose von Willebrand disease (VWD)
Differentiate between types of VWD (e.g., type 1, type 2A, 2B, 2M, 2N)
Assess functional activity of VWF in suspected bleeding disorders
Monitor response to VWF replacement therapy in certain patients
Evaluate unexplained prolonged bleeding time, easy bruising, or excessive bleeding after surgery or injury
Typical reference values for VWF GPIbM Activity are:
Normal range: ~50% to 150% (or 0.50–1.50 IU/mL), but exact cutoffs depend on the lab
Always interpret results alongside VWF antigen, VWF multimer analysis, Factor VIII, and platelet function tests.
Low activity suggests reduced or impaired function of von Willebrand factor, even if the amount of VWF is normal.
This can indicate:
Both VWF antigen and activity are reduced proportionally
Mild to moderate bleeding tendency
VWF antigen may be normal, but activity is significantly reduced
Subtypes:
Type 2A: Loss of high-molecular-weight multimers (essential for function)
Type 2B: Increased affinity for platelets (may cause thrombocytopenia)
Type 2M: Decreased function despite normal multimers
These types can lead to moderate or severe bleeding symptoms
Caused by autoimmune disorders, heart valve disease, certain cancers, or hypothyroidism
Undetectable or nearly absent VWF activity and antigen
Causes severe bleeding and usually diagnosed early in life
Elevated VWF activity is uncommon but may be seen in:
Inflammation or infection
Pregnancy
Stress or trauma
Diabetes
Cardiovascular disease
Liver disease (increased synthesis of clotting proteins)
Post-surgical or acute-phase states
High levels typically do not indicate disease, but in rare cases, very high VWF activity may contribute to thrombosis (excessive clotting), particularly in combination with other risk factors.
If your VWF GPIbM Activity is low, you may experience symptoms such as:
Easy bruising
Frequent nosebleeds
Heavy or prolonged menstrual bleeding
Bleeding gums
Excessive bleeding after dental work, surgery, or trauma
Prolonged bleeding time on minor cuts
You may be a candidate for VWF GPIbM testing if you:
Have unexplained bleeding symptoms
Have a family history of bleeding disorders
Have abnormal coagulation studies (e.g., prolonged aPTT or bleeding time)
Are being evaluated for von Willebrand disease
Need confirmation of a VWD subtype before treatment decisions
Are being monitored during VWF therapy or DDAVP (desmopressin) treatment
Sample type: Blood (plasma)
No special preparation is typically required
May be ordered along with:
VWF Antigen (VWF:Ag)
Factor VIII activity
VWF Collagen Binding (VWF:CB)
VWF Multimer Analysis
Platelet count and function tests
VWF GPIbM Activity is a modern, sensitive test that measures how well your von Willebrand factor binds to platelets — a critical step in normal blood clotting. It is essential in diagnosing von Willebrand disease, especially in detecting functional defects that may be missed by standard antigen tests. Whether you're being evaluated for a bleeding disorder or are already receiving treatment, this test provides a more accurate view of VWF activity and its impact on clotting function.
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After collecting lab results from different providers, you can download your entire history combined into a single file.
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
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There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
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For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
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All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
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Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
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To learn more about Healthmatters Pro, please refer to the professional page.
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Optimal Result:
50 - 200 BU/mL.