The Lymphocyte MAP
Whole Blood
Performed by: Cyrex Laboratories
Comprehensive Lymphocyte Immunophenotyping.
FEATURES:
1. Fourteen immunotypes uniquely designed to capture and highlight important immune trends revealed due to the comprehensive number of determinantions tested.
2. T-helper-1 or T-helper -2 Dominance (Immunotypes 6 and 7) includes the Cyrex Fluorescence Activated Cell Test (Cyrex FACT™), a breakthrough proprietary process developed by expert Cyrex immunologists, to classify Th1/Th2 balance or imbalance, based on the specific clusters of differentiation (CD markers) on the surface membranes on Th1 or Th2 cells, and not on the measurement of Th1/Th2-associated cytokine levels in the blood, commonly used by other laboratories.
3. Regulatory T cells or Tregs (Immunotype 8) maintain the balance between Th1 and Th2. A low number of Tregs may result in the breakdown in peripheral, central and oral tolerance, immune suppression, immune deficiencies, some autoimmune disorders, increased infections and cancer.
4. T-helper-17 dominance (Immunotype 9) includes the Cyrex FACT™ process based on direct measurement of cells based on the CD markers on their surface membranes of the cells, not by measuring IL-17 levels in the blood.
5. Patterns of disturbance in NK, cytotoxic NK and NK T cells. (Immunotypes 12 and 13) These immmunotypes are characterized by imbalanced natural killer (NK) cells, cytotoxic NK cells and NK T cells. They are the body’s soldiers whose job is to destroy different pathogens and varieties of cancer cells.
6. Immunotype with low or high CD57+ and its combination with CD16+ NK cells and CD8+ T cells. (Immunotype 14) CD57+ NK cells are highly differentiated long-lived cells that are more efficient in the killing of pathogen-infected cells and cancers, particularly during aging. Due to their efficiency at the killing of their targets, elevations in the number of CD57+ NK cells are associated with better outcomes for patients with cancers and some autoimmune diseases, while low levels are associated with lower overall survival from cancer.
CLINICAL USES:
- Measures the integrity of the immune system at the cellular level, identifying weaknesses or imbalances.
- Detects abnormalities in pre-disease stage providing a window of opportunity for early intervention.
- During active stage of disease, an abnormal LMAP can help design personalized treatment protocols for the patient.
- After treatment, follow up LMAP testing can help practitioners monitor the recovery progress of patients and effectiveness of specific medications.
The Lymphocyte MAP™ by Cyrex Laboratories is an innovative and comprehensive test panel designed to evaluate the immune system's functionality and integrity at the cellular level. This advanced diagnostic tool measures 29 key lymphocyte biomarkers and determinants, including Th1, Th2, CD4, CD8, Treg, Th17, and the family of NK cells.
Key features of the Lymphocyte MAP™ include its ability to capture and highlight important immune trends, made possible by the comprehensive number of determinants and biomarkers tested. The test utilizes the Cyrex Fluorescence-Activated Cell Test (FACT™), a proprietary process, for a more accurate representation of T-helper cell status. This advanced method differentiates between T-helper-1 (Th1) and T-helper-2 (Th2) dominance, as well as T-helper-17 (Th17) dominance, based on the specific clusters of differentiation (CD markers) on the surface membranes of the cells.
The Lymphocyte MAP™ is particularly useful for identifying underlying conditions triggering immune deficiencies, over-activity, infections, inflammation, autoimmunity, allergies, asthma, hypersensitivities, and cancers. It is beneficial for a wide range of patients, from those seeking optimal health and aging to those with autoimmune conditions or exposure to infections like COVID-19. The results from the test can assist healthcare practitioners in planning and monitoring treatment regimens aimed at achieving immune balance or harmony.
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Biomarkers included in this panel:
% B Cell
B cells, also known as B lymphocytes, are a crucial component of the adaptive immune system. They function primarily by producing antibodies against antigens, which are substances recognized as foreign by the immune system. These antibodies are speci
Learn more% CD3- CD57+ Lymphocyte
% CD57+ CD8+ T Cell
% Cytotoxic NK cells (CD16+)
The percentage of Cytotoxic NK (Natural Killer) cells expressing CD16+. CD16+, also known as FcγRIII, is a low affinity receptor for the Fc region of immunoglobulins G (IgG), found on the surface of NK cells, and plays a pivotal role in antibod
Learn more% NK Cell (CD56+)
The marker "% NK Cell (CD56+)" signifies the percentage of natural killer (NK) cells that express the CD56 antigen, a pivotal component in the assessment of immune health and functionality. NK cells, a critical subset of lymphocytes in the
Learn more% Regulatory T Cell
% T Cell
The "% T Cell" marker refers to the percentage of T cells in the lymphocyte population of the blood. T cells, a type of white blood cell, are central to the adaptive immune response, playing a pivotal role in immune regulation and response
Learn more% T-Helper (CD4) Cell
The marker % T-Helper (CD4) Cell is a critical parameter for assessing immune system health and functionality. T-Helper cells, also known as CD4+ cells, are a subset of lymphocytes that play a vital role in the immune response by activating and direc
Learn more% T-Helper-1 Cell
% T-Helper-17
The % T-Helper-17 (Th17) marker plays an important role in the evaluation of the immune system's state, particularly in the context of inflammation and autoimmunity. Th17 cells, a subset of T-helper cells, are primarily known for their involvemen
Learn more% T-Helper-2 Cell
The % T-Helper-2 Cell marker is a critical component in evaluating immune system functionality, particularly in the context of immune system balance and potential disorders. T-Helper-2 cells, often denoted as Th2 cells, are a subtype of T cells that
Learn moreT Cell/B Cell Ratio
The T Cell/B Cell Ratio is a sophisticated biomarker indicative of the adaptive immune system's balance and functionality. This ratio compares the quantity of T cells, which are primarily responsible for cell-mediated immunity, to B cells, which
Learn moreTh17/Treg Ratio
The Th17/Treg ratio is a critical marker offering significant insights into the immune system's regulatory mechanisms. Th17 cells (T-helper 17) and Treg cells (regulatory T cells) represent two distinct subsets of CD4+ T cells with opposing funct
Learn moreTotal B Cell
The Total B Cell marker is a critical indicator used to assess the status of B cells within the immune system. B cells, also known as B lymphocytes, play a pivotal role in the adaptive immune response, primarily responsible for the production of a
Learn moreTotal CD3- CD57+ Lymphocyte
The Total CD3- CD57+ Lymphocyte marker is offering insights into the immune system's state, particularly in the context of chronic infections and certain health conditions. This marker focuses on a subset of lymphocytes that are characterized by
Learn moreTotal CD57+ CD8+ T Cell
The Total CD57+ CD8+ T Cell marker plays a crucial role in immunological assessments. This marker is particularly significant because CD57+ CD8+ T cells are a subset of natural killer T cells (NKT cells) and cytotoxic T cells, which are integral comp
Learn moreTotal Cytotoxic NK cells (CD16+)
Total Cytotoxic NK (Natural Killer) cells, identified by the CD16+ marker, represent a crucial component in the innate immune system, playing a significant role in the body's first line of defense against tumors and virally infected cells. NK
Learn moreTotal NK Cell (CD56+)
Total NK cells (CD56+) represent a critical subset of lymphocytes pivotal for innate immunity, providing the first line of defense against tumors and a variety of pathogens. Natural Killer (NK) cells are characterized by their expression of the CD56
Learn moreTotal NKT (CD56+ CD16+ T Cell)
Total Regulatory T Cell (Treg)
Total Regulatory T cells (Treg) serve as a crucial marker for understanding immune regulation and potential autoimmune dysregulation within the body. Tregs, a subset of T cells characterized by the expression of CD4, CD25, and the transcription facto
Learn moreTotal T-Helper-1 Cell
The Total T-Helper-1 Cell marker serves as a critical component in the evaluation of immune system functionality, particularly in the adaptive immune response. T-Helper-1 (Th1) cells are a subset of CD4+ T cells, which are pivotal in orchestrating th
Learn moreTotal T-Helper-17 (Th17)
The Total T-Helper-17 (Th17) marker is a critical component in evaluating immune system functionality, particularly in the context of immune response regulation. T-Helper 17 (Th17) cells, a subset of pro-inflammatory T-helper cells, play a pivotal ro
Learn moreTotal T-Helper-2 Cell
Total T-Helper-2 (Th2) cells are a subset of the CD4+ T cells, playing a pivotal role in the adaptive immune response. They are characterized by their function in helping B cells to produce antibodies and are crucial in the defense against extracellu
Learn moreTotal WBC
The Total WBC (White Blood Cell) count measures the total number of white blood cells present in the blood, which are essential components of the immune system. White blood cells are responsible for defending the body against both infectious disease
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