Ceruloplasmin (BLOOD - SERUM)

Serum
check icon Optimal Result: 16 - 45 mg/dL.

What is Ceruloplasmin?

Ceruloplasmin is a copper-containing enzyme that plays a role in the body's iron metabolism. This test measures the amount of ceruloplasmin in the blood.

Function of copper:

Copper is an essential mineral that plays a role in the regulation of iron metabolism, formation of connective tissue, energy production at the cellular level, and the function of the nervous system. It is absorbed from food and liquids by the intestines and then transported to the liver, where it is stored or used to produce a variety of enzymes.

The liver binds copper to a protein to produce ceruloplasmin and then releases it into the bloodstream. About 95% of the copper in the blood is bound to ceruloplasmin. Because of this, the ceruloplasmin test can be used along with one or more copper tests to help diagnose Wilson disease, an inherited disorder that can lead to excess storage of copper in the liver, brain, and other organs.

When To Get Tested?

When you have jaundice, fatigue, abdominal pain, behavioral changes, tremors, or other symptoms that a health practitioner thinks may be due to Wilson disease or, rarely, to copper deficiency; at intervals when monitoring is recommended.

Test results:

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

References:

  • Diagnostic Value of Ceruloplasmin in the Diagnosis of Pediatric Wilson's Disease, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600703/
  • Ceruloplasmin and iron in Alzheimer’s disease and Parkinson’s disease: a synopsis of recent studies, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493298/

What does it mean if your Ceruloplasmin (BLOOD - SERUM) result is too high?

Your ceruloplasmin level can be higher than normal because of pregnancy, estrogen therapy, and birth control pills. Diseases such as leukemia, Hodgkin lymphoma, primary biliary cirrhosis, and rheumatoid arthritis can also cause a higher ceruloplasmin level. 

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What does it mean if your Ceruloplasmin (BLOOD - SERUM) result is too low?

Ceruloplasmin is a protein made by the liver that carries copper through your bloodstream and also plays a key role in iron metabolism. This test measures the amount of ceruloplasmin in your blood to help assess copper balance and related conditions.

A low ceruloplasmin level can indicate that your body isn't properly handling copper. This may be due to a genetic or acquired condition. Common causes of low ceruloplasmin include:

  • Wilson disease – A rare genetic disorder where copper builds up in the liver, brain, and other organs. 

  • Menkes disease – A genetic condition that affects copper absorption and transport, primarily seen in infants and young children.

  • Nephrotic syndrome – A kidney disorder that causes protein loss in the urine, which can lower ceruloplasmin levels.

  • Advanced liver disease – The liver makes ceruloplasmin, so liver damage can reduce production.

  • Malabsorption issues – Conditions like celiac disease or chronic diarrhea may impair nutrient and copper absorption.

  • Parkinson’s disease – Some studies have linked low ceruloplasmin levels with this neurological condition, though the relationship is still being studied.


Next Steps

If your ceruloplasmin level is low, your healthcare provider may recommend additional tests—such as copper levels, liver function tests, or genetic testing—to identify the underlying cause. Early diagnosis is important, especially for genetic or progressive conditions like Wilson disease.

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