Optimal Result:
0.4 - 1.61 ELISA Index.
Overview
The Cytoskeletal Proteins IgA marker measures immune reactivity to certain structural proteins that are part of the intestinal lining. These cytoskeletal proteins—most notably vinculin, talin, and alpha-actinin—help maintain the integrity of the gut's epithelial cells and tight junctions. These junctions are critical in regulating what passes from the inside of the gut into the bloodstream. When functioning properly, they help maintain a healthy, selective barrier that keeps out unwanted substances like toxins, bacteria, and partially digested food particles.
This test specifically measures Immunoglobulin A (IgA), an antibody type predominantly found in mucosal surfaces such as the gut. Elevated levels of IgA against cytoskeletal proteins can indicate that the immune system is responding to damage or stress at the intestinal lining, which may be the result of bacterial overgrowth, chronic inflammation, or previous gastrointestinal infections.
Why it’s tested
In conditions like Small Intestinal Bacterial Overgrowth (SIBO) or post-infectious Irritable Bowel Syndrome (IBS), certain pathogens—such as Campylobacter jejuni, E. coli, and Salmonella—can produce toxins that damage the epithelial cells lining the gut. One of the well-documented toxins involved in this process is the cytolethal distending toxin (Cdt), which can trigger an autoimmune-like immune response. When epithelial cells are injured, their cytoskeletal proteins are exposed to the immune system in abnormal ways. This may cause the immune system to treat those internal proteins as foreign, generating antibodies like IgA against them.
The presence of these antibodies reflects mucosal immune activation and may indicate a loss of immune tolerance to structural components of the gut lining. In other words, the immune system starts attacking the body's own tissue at the site of damage—an early sign of a more complex immune or inflammatory process that may not be limited to the digestive system.
Clinical relevance of elevated IgA
Elevated Cytoskeletal Proteins IgA levels suggest there may be ongoing damage or dysfunction in the intestinal barrier. This is important for several reasons:
Gut permeability (leaky gut): The integrity of the intestinal lining may be compromised, allowing bacteria, toxins, and food antigens to enter the bloodstream. This can lead to widespread inflammation and symptoms that go beyond the gut, such as joint pain, fatigue, or brain fog.
Post-infectious IBS and SIBO: Elevated antibodies to cytoskeletal proteins are commonly found in individuals with diarrhea-predominant IBS (IBS-D), especially after a gastrointestinal infection. In these cases, the immune response is driven by the aftermath of infection and can lead to long-term changes in gut motility and sensitivity.
Autoimmune risk: Persistent immune responses against self-proteins in the gut may contribute to the development of autoimmune conditions over time. The immune system's targeting of these proteins could spread to other tissues, particularly in individuals with genetic or environmental predispositions.
Barrier system cross-reactivity: Damage to the intestinal barrier may also affect other body systems that rely on similar barrier mechanisms, such as the blood-brain barrier or the lung epithelium. Cross-reactivity to structural proteins in multiple tissues is a growing area of research in immune-mediated diseases.
What this means for your health
If your Cytoskeletal Proteins IgA level is elevated, it suggests your immune system is reacting to structural proteins in your gut lining, likely in response to damage or chronic irritation. While this marker alone does not confirm a diagnosis, it provides useful insight when viewed in the context of other markers on the Array 22 panel—such as bacterial toxin antibodies (e.g., CdtB or LPS)—as well as your symptoms, history of infections, and digestive complaints.
Healthcare practitioners may use this information to support a diagnosis of post-infectious IBS, SIBO, or to guide personalized treatment strategies aimed at reducing immune activation, repairing the intestinal lining, and restoring a healthy microbial balance. This often includes dietary modifications, targeted antimicrobial therapy, probiotics, gut-healing nutrients like glutamine and zinc carnosine, and lifestyle changes to reduce systemic inflammation.
Summary
Cytoskeletal Proteins IgA is a powerful marker for identifying mucosal immune reactions in the gut. When elevated, it signals that your immune system may be targeting structural elements of the intestinal lining due to prior or ongoing damage—often related to SIBO, post-infectious IBS, or other inflammatory gut conditions. Addressing this immune reactivity early through targeted interventions can help support gut repair, prevent progression to broader immune dysregulation, and alleviate both digestive and systemic symptoms.
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If Cytoskeletal Proteins IgA is below the reference range or simply reported as within range by Cyrex Laboratories, it generally means that:
The immune system is not currently producing elevated levels of IgA antibodies against cytoskeletal proteins in the gut lining. This suggests that:
There may be no significant structural damage to intestinal epithelial cells.
There is likely no ongoing immune attack on gut barrier proteins like vinculin, talin, or alpha-actinin.
The gut mucosa is not reacting abnormally to prior infections or bacterial toxins at the time of testing.
A within-range result implies that the immune system is appropriately tolerating the body's own intestinal proteins, rather than mistakenly treating them as foreign threats. This is typically interpreted as a positive finding, particularly in the context of gut health and autoimmune risk.
Even if results are within range, they should be interpreted with clinical context:
A patient who had a past infection or gut damage may no longer have elevated IgA if the immune response has subsided or resolved.
In some cases, immunosuppressive medications, nutrient deficiencies (like IgA deficiency), or chronic immune exhaustion may blunt antibody responses—even in the presence of active tissue injury. This is less common but clinically relevant.
If you're asymptomatic or improving, a normal result supports the idea that the gut barrier is stable.
If you still have significant digestive symptoms (bloating, diarrhea, post-infectious IBS), your provider may look at other markers on Array 22, such as:
Anti-CdtB (cytolethal distending toxin B)
LPS IgG/IgA/IgM (lipopolysaccharide antibodies)
These can help determine if bacterial toxin exposure or other immune activity is present despite a normal cytoskeletal protein IgA level.
A within-range or low Cytoskeletal Proteins IgA result typically suggests that:
The intestinal mucosal barrier is not under active immune attack.
There is no current antibody response targeting gut structural proteins.
This is considered a normal and favorable finding, especially when consistent with a lack of significant symptoms or when supported by other normal immune markers.
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Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey. Whether you're tracking a condition, managing treatments, or staying proactive, the timeline helps you and your doctor understand how things progress over time.
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.
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Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.
Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
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Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
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View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
Export Your Complete Lab History in a Single File
Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
Comprehensive Data Entry Service for Your Reports
Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
Securely Share With Anyone You Trust
Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
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There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
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All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
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The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
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Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
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Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
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