Atypical lymphocytes, quantified as x10^9/L on a White Blood Cell (WBC) Differential panel, are a crucial diagnostic marker, indicative of various pathological conditions. These cells, larger than typical lymphocytes, often exhibit irregular shapes and a more abundant cytoplasm, which can be either pale or deeply basophilic. Their nucleus may be lobulated or indented, contrasting with the typical round or slightly indented nucleus of standard lymphocytes.

Atypical perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) occur in most patients with ulcerative colitis but only in a minority of those with Crohn's disease.

Augmentin, a widely used antibiotic, is a combination of two active ingredients: amoxicillin, a penicillin-type antibiotic, and clavulanic acid, a beta-lactamase inhibitor. This combination is designed to enhance the effectiveness of amoxicillin by overcoming certain types of antibiotic resistance. Amoxicillin works by inhibiting bacterial cell wall synthesis, effectively killing or stopping the growth of bacteria. However, many bacteria have developed resistance to amoxicillin through the production of beta-lactamase enzymes, which break down the antibiotic before it can act. Clavulanic acid in Augmentin inhibits these enzymes, thereby protecting amoxicillin from degradation and expanding its spectrum of activity. This makes Augmentin effective against a broader range of bacteria compared to amoxicillin alone, including many that are resistant to other penicillins.

It is a commonly encountered species in wet buildings. It is both a soil and leaf fungus.

Abnormal levels of Aureobasidi Pullulans may indicate an allergic sensitivity or hypersensitivity reaction to the fungus Aureobasidi pullulans, which is commonly found in environments such as damp areas, moldy buildings, and agricultural settings. Elevated levels suggest an overactive immune response to this fungal allergen, which may contribute to symptoms like asthma, allergic rhinitis, or other respiratory issues. Testing for this marker can help in diagnosing mold-related allergies and guide treatment strategies to manage allergic reactions.

Treatment for an allergy to Aureobasidi pullulans typically involves avoiding exposure to environments where the fungus is prevalent, such as damp or moldy areas. Medications such as antihistamines, nasal corticosteroids, or leukotriene modifiers can help manage symptoms like nasal congestion or sneezing. For more severe reactions, immunotherapy (allergy shots) may be recommended to desensitize the immune system to the allergen over time. In some cases, if asthma is present, bronchodilators or inhaled corticosteroids may be prescribed to manage respiratory symptoms.

The marker "Average DHEA-S" (Dehydroepiandrosterone Sulfate) is a critical indicator of adrenal gland function and overall androgen status in women. DHEA-S, a sulfated form of DHEA, is one of the most abundant circulating steroids in the human body and serves as a precursor for both androgens and estrogens. It is predominantly produced in the adrenal glands, with its levels reflecting adrenal function.

Elevated levels of DHEA-S can be associated with conditions like polycystic ovary syndrome (PCOS), adrenal hyperplasia, or adrenal tumors, and can lead to symptoms such as hirsutism, acne, and menstrual irregularities. On the other hand, low levels of DHEA-S might indicate adrenal insufficiency, aging, or chronic stress, which can manifest in fatigue, weakness, and decreased libido.

Elevated antibody levels can be clinically significant — while the antibodies themselves don’t destroy anything, they do trigger an inflammatory response that can cause significant destruction of tissue and resulting symptoms. This response is not necessarily dependent on antibody levels. However, an equivocal result may mean you are just beginning to exhibit an immune reaction, so this is an important time to take measures to support the body in damping immune reactivity.

β-alanine is a breakdown product of carnosine and anserine, which are dipeptides from meat consumption. Although β-alanine’s properties are limited, its relationship to carnosine makes it important. Both have antioxidant properties. And carnosine is critical for pH buffering in skeletal muscle during exercise, but its formation can be limited by enzymatic factors. For this reason, supplementation with β-alanine is sometimes used to enhance carnitine and therefore improve athletic performance.

β-alanine is a breakdown product of carnosine and anserine, which are dipeptides from meat consumption. Although β-alanine’s properties are limited, its relationship to carnosine makes it important. Both have antioxidant properties. Carnosine is critical for pH buffering in skeletal muscle during exercise, but its formation can be limited by enzymatic factors.

For this reason, supplementation with β-alanine is sometimes used to enhance carnitine and therefore improve athletic performance. In addition to diet and supplementation, β-alanine can also be endogenously produced. This occurs via degradation of uracil in the liver but it can also be made by intestinal bacteria such as E. coli.

β-alanine is a breakdown product of carnosine and anserine, which are dipeptides from meat consumption. Although β-alanine’s properties are limited, its relationship to carnosine makes it important. Both have antioxidant properties. Carnosine is critical for pH buffering in skeletal muscle during exercise, but its formation can be limited by enzymatic factors.

For this reason, supplementation with β-alanine is sometimes used to enhance carnitine and therefore improve athletic performance. In addition to diet and supplementation, β-alanine can also be endogenously produced. This occurs via degradation of uracil in the liver but it can also be made by intestinal bacteria such as E. coli.

Beta-alanine is a non-essential amino acid.

What are amino acids?

The body can make Non-essential amino acids, so they don’t have to be provided by food. Amino acids are the building blocks of proteins.

Beta-aminoisobutyric acid (also known as 3-aminoisobutyric acid) is a non-protein amino acid formed by the catabolism of valine and the nucleotide thymine. It is further catabolized to methylmalonic acid semialdehyde and propionyl-CoA. Levels are controlled by a vitamin B6-dependent reaction in the liver and kidneys. β-aminoisobutyric acid can also be produced by skeletal muscle during physical activity.

Beta-aminoisobutyric acid (also known as 3-aminoisobutyric acid) is a non-protein amino acid formed by the catabolism of valine and the nucleotide thymine. It is further catabolized to methylmalonic acid semialdehyde and propionyl-CoA.

Levels are controlled by a vitamin B6-dependent reaction in the liver and kidneys.

β-aminoisobutyric acid can also be produced by skeletal muscle during physical activity.

Beta-aminoisobutyric acid (also known as 3-aminoisobutyric acid) is a non-protein amino acid formed by the catabolism of valine and the nucleotide thymine. It is further catabolized to methylmalonic acid semialdehyde and propionyl-CoA. Levels are controlled by a vitamin B6-dependent reaction in the liver and kidneys. β-aminoisobutyric acid can also be produced by skeletal muscle during physical activity.

Beta-aminoisobutyric acid (BAIB) is an amino acid end product of the pyrimidine metabolism. It is excreted in small quantities into the urine in almost all human beings. Thymine, released when RNA and DNA are degraded, enters a catabolic pathway that leads to Beta-Aminoisobutyric Acid.

Beta-Carotene is an oxidative stress marker.

– Beta-Carotene is involved in antioxidant protection.

– Beta-carotene is converted into vitamin A in the liver.

– Beta-carotene & other carotenoids are converted to vitamin A (retinol), involved in vision, antioxidant & immune function, gene expression & cell growth.

Beta-glucuronidase is an enzyme that breaks the tight bond between glucuronic acid and toxins in the intestines. The liver and intestine bind toxins, steroid hormones and some dietary components to glucuronic acid. That is a protective process that limits absorption and enterohepatic reabsorption of toxins, and enhances excretion. A high level of activity of Beta-glucuronidase in the gut is not desirable. A low level of Beta-glucuronidase activity is not known to be of any direct clinical consequence.

The marker "β-glucuronidase producing bacteria" is a significant indicator of the bacterial enzyme activity within the gut microbiome. β-glucuronidase is an enzyme produced by certain bacteria that plays a crucial role in the metabolism of complex carbohydrates and the processing of various substances within the intestines. This enzyme helps to break down glucuronides, which are compounds that the body uses to detoxify and eliminate waste, including hormones, toxins, and pharmaceuticals, by attaching glucuronic acid to them, making them more water-soluble and easier to excrete through the bile or urine.

The presence and level of β-glucuronidase producing bacteria in your gut can provide valuable insights into your intestinal health and function. Elevated levels of this enzyme can lead to the reactivation of potentially harmful substances that were meant to be excreted, contributing to various health issues, including hormone imbalance, increased risk of certain cancers, and impaired detoxification processes. Conversely, too low levels may indicate a compromised ability to break down and eliminate waste properly. Understanding the balance and activity of β-glucuronidase producing bacteria through the Gut Zoomer panel allows healthcare providers to tailor specific dietary, lifestyle, and possibly supplementation interventions aimed at optimizing gut health, supporting detoxification processes, and ultimately contributing to overall well-being.