Cow's Milk
Part of Array 4 - Gluten-Associated Cross-Reactive Foods and Foods Sensitivity, Cyrex Laboratories

Antigen Made From: Raw and pasteurized Cow's Milk Associated With: - Behçet’s disease - Celiac disease - Dairy allergy - Diabetes - Lupus Known Cross-Reactions: Gliadin; Buffalo milk, Sheep milk, Goat milk; Triiodothyronine (T3) Clinical Significance: The presence of antibodies to Cow’s Milk is an indication of food immune reactivity. The offending food and its known cross-reactive foods should be eliminated from the diet. Bellioni et al. found that 92% of subjects with an allergy to cow’s milk showed reactivity to goat’s milk. Cow’s Milk is the most common cause of food allergy in the first years of life; although most children outgrow the allergy by age 3 or 4. For some, the immune reactivity persists throughout one’s lifetime and may contribute to autoimmunity later in life. Particular autoimmunities associated with Cow’s Milk include Type 1 Diabetes, Behçet’s disease and Systemic Lupus Erythematosus. Cow’s Milk plays a role in the gastrointestinal symptoms in 50% of patients with non-celiac gluten sensitivity and Celiac disease. References: 1. Triolo et al. humoral and cell-mediated immune response to cow’s milk proteins in Behçet’s disease. Ann Rheum Dis, 2002; 61:459-462. 2. Kristjánsson et al. Mucosal reactivity to cow’s milk protein in celiac disease. Clin Exp Immunol, 2007; 147:449-455. 3. Järvinen et al. B-cell epitopes as a screening instruments for persistent cow’s milk allergy. J Allergy Clin Immunol, 2002; 110:293-297. 4. Karjalainen et al. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med, 1992; 327:302-307. 5. Monetini et al. Establishment of T cell lines to bovine beta-casein and beta-casein-derived epitopes in patients with type 1 diabetes. J Endocrinol, 2003; 176:143-150. 6. Riemekasten et al. Casein is an essential cofactor in autoantibody reactivity directed against the C-terminal SmD1 peptide AA83-119 in systemic lupus erythematosus. Immunobiology, 2002; 206:537-545. 7. Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32. 8. Restani et al. Cross-reactivity between milk proteins from different animal species. Clin Exp Allergy, 1999; 29(7):997-1004. 9. Bellioni et al. Allergenicity of goat’s milk in children with cow’s milk allergy. J Allergy Clin Immunol, 1999; 103:1191-1194. 10. Kharrazian, et al. Immunological reactivity using monoclonal and polyclonal antibodies of autoimmune thyroid target sites with dietary proteins. J Thyroid Res, 2017; 2017:4354723.

Optimal range 0 – 2 ELISA Index Learn more