Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Estriol is considered to be the mildest and briefest-acting of the three estrogens.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Estriol (E3) is considered to be the mildest and briefest-acting of the three estrogens.

Estrogens play a critical role in female sexual development, menstrual function, protein synthesis, cardiovascular function, bone formation and remodeling, cognitive function, emotional balance and other important health factors.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

Evaluation of the estrogen metabolism pathway relies on understanding several key steps of metabolism: the amount of unconjugated estrogens, hydroxylation of E1 and E2, methylation of hydroxy estrogens, and the function of key enzymes.

Evaluation of the estrogen metabolism pathway relies on understanding several key steps of metabolism: the amount of unconjugated estrogens, hydroxylation of E1 and E2, methylation of hydroxy estrogens, and the function of key enzymes.

Estriol is the weakest of the three major naturally-occurring estrogens in women. It is a product of the metabolism of estrone and estradiol and is excreted in the urine in greater amounts than estradiol. Because of its weak estrogenic activity, estriol is sometimes preferred for intravaginal use as an alternative to systemic estrogen therapy for the treatment of urogenital atrophy in postmenopausal women. It is also used in anti-aging skin creams as a form of topical estrogen replacement to counteract the effects of age-related estrogen loss on skin.

Estriol is the major estrogen found in the maternal circulation during pregnancy; 90% of this circulating estriol is the product of metabolism of DHEA from the fetal adrenals, and so maternal estriol levels are used as an indicator of fetal health. In non-pregnant women, estriol levels are similar in both pre– and post-menopause, and are also similar to levels in men. The saliva test for estriol has been found to be predictive of increased risk of preterm labor in pregnant women. In non-pregnant women it is most commonly used for monitoring of levels in women using estriolcontaining supplements as part of hormone replacement therapy.

In the context of a Hormone Metabolite Assessment Panel (HUMAP) for pre-menopausal women, Estriol plays a unique and informative role in the spectrum of estrogen metabolites. Estriol, a weaker estrogen compared to estradiol and estrone, is predominantly known for its significance during pregnancy, where its levels rise markedly. However, in non-pregnant, pre-menopausal women, estriol is present in much lower amounts and is a product of the metabolism of other estrogens. Its levels in a HUMAP panel provide insights into the body's estrogen metabolism pathways and overall hormonal balance.

Estriol is the weakest of the three major naturally-occurring estrogens in women.

Estriol is a product of the metabolism of estrone and estradiol. Because of its weak estrogenic activity, estriol is sometimes preferred for intravaginal use as an alternative to systemic estrogen therapy for the treatment of urogenital atrophy in postmenopausal women.

It is also used in anti-aging skin creams as a form of topical estrogen replacement to counteract the effects of age-related estrogen loss on skin. Estriol is the major estrogen found in the maternal circulation during pregnancy; 90% of this circulating estriol is the product of metabolism of DHEA from the fetal adrenals, and so maternal estriol levels are used as an indicator of fetal health.

In non-pregnant women, estriol levels are similar in both pre- and post-menopause and are also similar to levels in men. Salivary estriol has been found to be predictive of increased risk of preterm labor in pregnant women. In nonpregnant women, it is most commonly used for monitoring of levels in women using estriol-containing supplements as part of hormone replacement therapy.

Estriol is one of three estrogen hormones. Estriol levels rise throughout pregnancy, helping to keep your uterus and unborn baby healthy. The levels are at their highest right before childbirth. They help prepare your body for labor and delivery.

Everyone makes estriol. But in people who aren’t pregnant, the levels are almost undetectable. Other names for estriol include oestriol and E3.

During pregnancy, estriol:

- Helps your uterus grow as the fetus gets bigger.
- Makes your body more sensitive to other pregnancy hormones.
- Prepares your body for labor and delivery and breastfeeding.

Patients with an EQ>1 have a higher survival rate after breast cancer, and may be at decreased risk for developing breast cancer. EQ often declines as women enter menopause.

The estrobolome is a network of over 60 genera of bacteria that can recycle or deconjugate inactivated estrogens for reabsorption into circulation by producing very powerful enzymes. This recycling process is handled by gut bacteria with beta-glucuronidase and beta-glucosidase activity. When the estrobolome is too abundant, the body is unable to efficiently eliminate estrogen, causing estrogens to build up and ultimately leading to estrogen dominance. On the other hand, if estrogen recycling (estrobolome) is too low, then this may lead to insufficient levels of estrogen in circulation.

Total estrogen is a reliable test for estrogen status and is used to detect hormone imbalances.

Estrogen is known as the “female” hormone. The four major naturally occurring estrogens in women are estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4).

Normal Ranges for Total Estrogen in pg/mL:

Critical Range: anything outside the limits mentioned above.

Estrogen is known as the “female” hormone. The four major naturally occurring estrogens in women are estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4).

Although estrogen is identified with females, it is also found in men.