Elevated in mitochrondrial disorders. Aconitase metabolizes citric and aconitic acids, and is dependent on glutathione.

Elevated in mitochrondrial disorders. Aconitase metabolizes citric and aconitic acids, and is dependent on glutathione.

Elevated in mitochrondrial disorders. Aconitase metabolizes citric and aconitic acids, and is dependent on glutathione.

Elevated in mitochrondrial disorders. Aconitase metabolizes citric and aconitic acids, and is dependent on glutathione.

Elevated in mitochrondrial disorders. Aconitase metabolizes citric and aconitic acids, and is dependent on glutathione.

ACTH (Adrenocorticotropic hormone), a pituitary hormone, stimulates cortisol production from the adrenal glands. If ACTH levels are too low or too high, it can indicate that the pituitary or the adrenal glands are diseased.

Actin (Smooth Muscle) Antibody (IgG) - Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis.

F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls.

Actinobacteria is one of the largest bacterial phyla, comprised of Gram-positive bacteria.

Actinobacteriota, formerly known as Actinobacteria, is a significant phylum within the gut microbiota that plays a crucial role in human health. On an adult gut health test, Actinobacteriota serves as a marker for assessing various aspects of gut function, including digestion, immune regulation, and the production of beneficial metabolites. This phylum is well known for containing bacterial genera such as Bifidobacterium, which are associated with positive health outcomes, including the production of short-chain fatty acids (SCFAs), modulation of inflammation, and inhibition of harmful pathogens.

One of the primary functions of Actinobacteriota in the gut is its involvement in carbohydrate metabolism. Many species within this group are adept at breaking down complex carbohydrates and fibers, which are not digestible by human enzymes, into SCFAs like acetate and butyrate. These metabolites serve as an energy source for colon cells, help maintain the integrity of the gut lining, and contribute to a balanced inflammatory response. Therefore, a healthy level of Actinobacteriota on a gut health test is often seen as indicative of a diet rich in fiber and prebiotics, which supports overall gut health.

However, an imbalance in Actinobacteriota levels can be a marker of gut dysbiosis, a condition where the microbial community in the gut is disturbed. Low levels of beneficial bacteria like Bifidobacterium may indicate poor digestion of fiber, reduced SCFA production, and a higher risk of inflammatory conditions such as irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). Conversely, an overgrowth of certain Actinobacteriota species, particularly pathogenic strains, could be associated with conditions like small intestinal bacterial overgrowth (SIBO) or contribute to metabolic disorders.

Actinomycetales are considered low abundance colonizers of the gastrointestinal tract with primary residence on the skin.

The Activated CD21low CD38- % biomarker measures the proportion of B cells with low CD21 expression and absent CD38 expression, representing a subset of atypical or activated B cells linked to immune dysregulation. These cells are associated with chronic immune activation (e.g., in HIV or hepatitis), autoimmune diseases (e.g., lupus, rheumatoid arthritis), and primary immunodeficiencies (e.g., CVID). They are often indicative of B cell exhaustion caused by prolonged antigen exposure. Elevated levels may signal chronic activation or autoimmune pathology, while interpretation requires clinical context, additional immune markers, and other laboratory findings to assess immune status effectively.

Activated CD21low CD38- B cells are a distinct subset of B lymphocytes associated with chronic immune activation and immune dysregulation. These cells exhibit low CD21 expression, absence of CD38, elevated activation markers like CD80 and CD86, and increased inhibitory receptors such as PD-1 and FCRL4. They produce class-switched antibodies, predominantly IgG and IgA, which often include autoreactive antibodies and those targeting persistent antigens. These cells play a role in chronic inflammation, autoantibody production, and disrupted immune tolerance, commonly linked to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, as well as chronic infections like HIV and hepatitis C. Reduced responsiveness to signaling pathways and cytokine secretion, including IL-6 and TNF-α, highlight their contribution to immune dysfunction. Monitoring these cells and their antibodies provides insights into chronic immune activation, autoimmune processes, and the efficacy of immunomodulatory therapies, making them valuable markers in diagnostics and disease management.

The Activated partial thromboplastin time (aPTT) test tells you how many seconds (s) it takes your blood to form a clot after body tissue(s) or blood vessel walls were injured.

Screening test for the factor V Leiden gene mutation and other causes of activated protein C resistance

Activated Vitamin B12, also known as holotranscobalamin (holo-TC), is a significant biomarker for Vitamin B12 status in the body. Unlike total B12, which measures both active and inactive forms, holo-TC specifically indicates the amount of Vitamin B12 that is available for cellular uptake and use. This makes it a more precise marker for assessing B12 deficiency, especially in clinical situations where accurate diagnosis is crucial.

Activated Vitamin B12, also known as holotranscobalamin (holo-TC), is a significant biomarker for Vitamin B12 status in the body. Unlike total B12, which measures both active and inactive forms, holo-TC specifically indicates the amount of Vitamin B12 that is available for cellular uptake and use. This makes it a more precise marker for assessing B12 deficiency, especially in clinical situations where accurate diagnosis is crucial.

In a semen analysis, "active sperm" typically refers to sperm motility. Active sperm are those that are capable of moving, and sperm motility is an important parameter in assessing male fertility.