The Deamidated Gliadin Peptide Immunoglobulin A (DGP IGA) marker plays a pivotal role in the celiac disease diagnostic process, offering unique insights that complement other testing methods in a celiac panel. This test specifically measures the IGA antibodies against deamidated gliadin peptides, which are a form of gliadin (a key component of gluten) that has been modified during the digestive process. The presence of these antibodies indicates an immune response to gluten, characteristic of celiac disease.
What sets the DGP IGA test apart is its high sensitivity and specificity, particularly in certain patient groups. It is especially valuable in young children, under the age of two, where classic celiac disease markers like Tissue Transglutaminase Immunoglobulin A (TTG IGA) may not be as reliable. In these cases, DGP IGA can provide a more accurate reflection of the immune response to gluten. Additionally, DGP IGA testing is beneficial in cases where individuals have already started a gluten-free diet prior to testing, as it can remain positive for a longer period after gluten has been removed from the diet, unlike TTG IGA which may quickly normalize.
In the broader context of celiac disease testing, the DGP IGA test is typically used in conjunction with TTG IGA. The combined use of these tests enhances the overall diagnostic accuracy, particularly when there is a suspicion of celiac disease despite negative or borderline TTG IGA results. However, elevated DGP IGA levels alone are not definitive for celiac disease. A positive result must be corroborated with other clinical findings, patient symptoms, and possibly an intestinal biopsy, which remains the gold standard for diagnosing celiac disease.
Furthermore, while elevated DGP IGA levels are strongly suggestive of celiac disease, they can occasionally be seen in other conditions. Therefore, a positive DGP IGA test should always be interpreted in the context of the entire clinical picture by healthcare professionals.
In summary, the DGP IGA marker is a valuable tool in the celiac panel, offering specific advantages in certain populations and situations. Its role in conjunction with other celiac tests underscores the complexity of diagnosing this autoimmune condition and highlights the importance of a comprehensive, multi-faceted diagnostic approach.
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What do normal DGP IGA levels mean in general?
Normal levels of DGP IGA (Deamidated Gliadin Peptide Immunoglobulin A) in a celiac disease panel can signify several things, depending on the context and the presence of other test results:
→ Low Likelihood of Active Celiac Disease: In individuals being tested for celiac disease, normal DGP IGA levels, especially when combined with normal levels of other celiac-specific tests like TTG IGA (Tissue Transglutaminase Immunoglobulin A), suggest a low likelihood of active celiac disease. This is particularly relevant if the individual is currently consuming a diet containing gluten.
→ Consideration of IGA Deficiency: It's important to consider the total serum IGA level. If an individual has an IGA deficiency (which can occur in a small percentage of the population), the DGP IGA test may not be reliable, as the body produces insufficient IGA antibodies. In such cases, IgG-based celiac tests (like TTG IgG or DGP IgG) would be more appropriate.
→ Age Factor in Children: The DGP IGA test is often used in very young children, under two years of age, as it can be more sensitive than TTG IGA in this age group. Normal DGP IGA levels in this context might lower the suspicion of celiac disease, but it's important to consider the entire clinical picture.
→ Possibility of Gluten-Free Diet Effect: If an individual has already started a gluten-free diet prior to testing, normal DGP IGA levels might not necessarily rule out celiac disease. This is because the levels of antibodies can decrease once gluten is removed from the diet.
→ Exclusion of Other Conditions: While elevated DGP IGA levels can occasionally be seen in conditions other than celiac disease, normal levels generally do not indicate these other conditions.
→ Need for Further Evaluation: If clinical suspicion of celiac disease remains high despite normal DGP IGA levels, further evaluation, including other antibody tests (like TTG IGA, TTG IgG, and EMA) and possibly an endoscopic biopsy, may be necessary.
→ Monitoring and Follow-Up: In diagnosed celiac disease patients undergoing treatment (gluten-free diet), normal DGP IGA levels can indicate a good compliance with the diet and a positive response to treatment.
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What if DGP IGA levels are within the normal range and TTG IGA levels are elevated?
If DGP IGA (Deamidated Gliadin Peptide Immunoglobulin A) levels are within the normal range but TTG IGA (Tissue Transglutaminase Immunoglobulin A) levels are elevated in a celiac disease panel, this scenario requires a careful interpretation. Here's how these results are generally approached:
→ Strong Indication of Celiac Disease: Elevated TTG IGA levels are highly indicative of celiac disease, as this marker is very sensitive and specific for the condition. TTG IGA is considered a primary screening test for celiac disease, and its elevation is a strong predictor, especially in individuals who are consuming a gluten-containing diet.
→ Variable Sensitivity of DGP IGA: While DGP IGA is also specific for celiac disease, it might not always be elevated in every case. The sensitivity of the DGP IGA test can vary based on factors like age and the degree of intestinal damage. It is often more useful in specific populations, such as young children.
→ Clinical Correlation: The test results should be correlated with the patient’s symptoms and clinical history. Celiac disease can present with a wide range of symptoms, from gastrointestinal issues to more systemic manifestations.
→ Consideration of Total Serum IGA: It's important to ensure that the individual is not IGA deficient, as this could affect the reliability of IGA-based tests. In cases of IGA deficiency, TTG IgG and DGP IgG tests might be more appropriate.
→ Intestinal Biopsy for Confirmation: Given the elevated TTG IGA, an intestinal biopsy is often recommended to confirm the diagnosis of celiac disease. The biopsy can directly assess the damage to the intestinal villi, which is a hallmark of celiac disease.
→ Other Conditions: While less common, it's important to note that elevated TTG IGA levels can occasionally be seen in conditions other than celiac disease, such as liver disease or other autoimmune disorders. However, these are much less likely in the absence of other supporting evidence for these conditions.
→ Professional Interpretation: The interpretation of these test results should be carried out by healthcare professionals who can integrate the lab findings with the clinical picture. This ensures a more accurate diagnosis and appropriate management plan.
In summary, elevated TTG IGA levels with normal DGP IGA levels still strongly suggest celiac disease, particularly when clinical symptoms are consistent with this condition. Further diagnostic steps, such as an intestinal biopsy, are typically pursued to confirm the diagnosis and guide treatment.
Elevated Deamidated Gliadin Peptide Immunoglobulin A (DGP IGA) levels are a notable marker in celiac disease diagnostics, particularly effective in young children where traditional tests like Tissue Transglutaminase IGA (TTG IGA) may be less reliable. These elevated levels indicate an immune response to gluten, strongly suggestive of celiac disease, but should be interpreted with caution as they can occasionally yield false positives in other conditions. For a definitive diagnosis, elevated DGP IGA results are typically considered alongside other celiac-specific tests and clinical symptoms, and they are often corroborated with an intestinal biopsy, which remains the gold standard for confirming celiac disease. Additionally, in diagnosed patients, persistently high DGP IGA levels can indicate gluten exposure or non-adherence to a gluten-free diet, necessitating a reevaluation of dietary compliance.
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What if DGP IGA and TTG IGA are elevated?
If both DGP IGA (Deamidated Gliadin Peptide Immunoglobulin A) and TTG IGA (Tissue Transglutaminase Immunoglobulin A) levels are elevated in a celiac disease panel, it strongly suggests the presence of celiac disease. This combination of test results indicates a significant immune response against gluten:
→ High Probability of Celiac Disease: Elevated TTG IGA is a primary marker and highly specific for celiac disease, indicating an autoimmune reaction where the body mistakenly targets its own tissue transglutaminase enzyme. Elevated DGP IGA, which measures the immune response to a specific form of gliadin (a component of gluten), further supports this diagnosis.
→ Consistent with Clinical Symptoms: The elevation in both markers should be correlated with clinical symptoms typical of celiac disease, which can range from gastrointestinal issues to systemic symptoms like anemia, fatigue, or bone density loss.
→ Reduced Likelihood of False Positives: While each test individually can have false positives in certain conditions, the likelihood of both tests being elevated due to reasons other than celiac disease is considerably lower.
→ Confirmation with Biopsy: To confirm the diagnosis, an intestinal biopsy is often recommended. This procedure can reveal the characteristic villous atrophy caused by the immune reaction in celiac disease.
→ Comprehensive Evaluation: The results should be evaluated in the context of the patient's overall health, including any other autoimmune disorders, as celiac disease can be associated with other autoimmune conditions.
→ Guidance for Treatment: A diagnosis confirmed through these tests typically leads to the initiation of a strict gluten-free diet, the main treatment for celiac disease, and further monitoring to assess the patient's response to dietary changes.
In conclusion, elevated levels of both DGP IGA and TTG IGA in a celiac panel are a strong indicator of celiac disease, warranting further diagnostic steps and a comprehensive evaluation to confirm the diagnosis and guide appropriate treatment.
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About membership
Import Lab Results from Any Source
Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.
Easily upload lab results from any provider — we support PDFs, scans, and images. Keep all your reports organized in one secure place.
See Your Health Timeline
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey. Whether you're tracking a condition, managing treatments, or staying proactive, the timeline helps you and your doctor understand how things progress over time.
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.
Understand What Your Results Mean
Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.
Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
Enter Your Lab Reports Yourself — Always Free
Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
Visualize Your Results
View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
Export Your Complete Lab History in a Single File
Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
Comprehensive Data Entry Service for Your Reports
Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
Securely Share With Anyone You Trust
Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Anthony
Unlimited Plan Member since 2021
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Karin
Advanced Plan Member since 2020
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Paul
Healthmatters Pro Member since 2024
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
With a Healthmatters account, you can:
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
Optimal Result:
0 - 14.9 U/mL.