Leukocyte esterase is a screening test used to detect a substance that suggests there are white blood cells in the urine. This may mean you have a urinary tract infection.
If this test is positive, the urine should be examined under a microscope for white blood cells and other signs that point to an infection.
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An elevated or abnormal level of leukocyte esterase in a urinalysis indicates the presence of white blood cells (WBCs) or their enzymes in the urine, which is a common marker for inflammation or infection within the urinary tract. Leukocyte esterase is an enzyme found in white blood cells, and its detection in urine usually points to a urinary tract infection (UTI), including infections of the bladder (cystitis), urethra (urethritis), or kidneys (pyelonephritis). However, it can also indicate inflammation that is not caused by an infection, such as with some sexually transmitted infections (STIs) or other forms of kidney inflammation. Elevated levels of this enzyme suggest that the body is responding to a problem by sending white blood cells to the affected area, implying an immune response. While a positive leukocyte esterase test is a strong indicator of a UTI or other urinary tract issues, it is typically followed up with further testing, such as a urine culture, to identify the specific cause and to guide appropriate treatment.
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