The SCL-70 antibody test is a blood test used to detect antibodies against topoisomerase I, an enzyme found in the nucleus of cells. These antibodies are part of the antinuclear antibody (ANA) family and are often associated with certain autoimmune conditions—most notably systemic sclerosis (scleroderma).

This test helps doctors evaluate symptoms such as skin thickening, joint pain, fatigue, or shortness of breath that may be related to autoimmune diseases.

ADMA/SDMA may be measured in individuals with multiple risk factors for the development of CVD.

SDMA is primarily excreted in the urine and identifies reduced renal function.

One of the earliest manifestations of endothelial dysfunction is nitric oxide (NO) deficiency, which promotes atherosclerosis. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), its structural isomer, are metabolites of L-arginine, an amino acid that is catalyzed to L-citrulline and NO by nitric oxide synthase (NOS).

Both ADMA and SDMA have distinct pathophysiologies and manifestations. ADMA is a competitive inhibitor of NOS thereby reducing NO production and promoting endothelial dysfunction. SDMA also interferes with NO production, but does so indirectly by reducing the cellular availability of arginine. ADMA is primarily cleared through enzymatic degradation in the bloodstream and its presence identifies subclinical cardiovascular disease (CVD). Conversely, SDMA is primarily excreted in the urine and identifies reduced renal function.

Increased urinary products of the omega fatty acid metabolism pathway may be due to carnitine deficiency, fasting, or increased intake of triglycerides from coconut oil, or some infant formulas.

Increased urinary products of the omega fatty acid metabolism pathway may be due to carnitine deficiency, fasting, or increased intake of triglycerides from coconut oil, or some infant formulas.

Increased urinary products of the omega fatty acid metabolism pathway may be due to carnitine deficiency, fasting, or increased intake of triglycerides from coconut oil, or some infant formulas.

Increased urinary products of the omega fatty acid metabolism pathway may be due to carnitine deficiency, fasting, or increased intake of triglycerides from coconut oil, or some infant formulas.

Increased urinary products of the omega fatty acid metabolism pathway may be due to carnitine deficiency, fasting, or increased intake of triglycerides from coconut oil, or some infant formulas.

Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.

Immunoglobulin A (IgA) is an antibody playing a critical role in mucosal immunity and is produced in greater quantities than all other types of antibody combined.

In its secretory form, Secretory IgA is the main immunoglobulin found in mucous secretions and provides protection against potentially pathogenic microbes, due to its ability to resist degradation by enzymes and survive in harsh environments such as GI and respiratory tracts.

As the most abundant class of antibody found in the human intestinal lumen, secretory IgA (sIgA) is recognized as a first line of defense in protecting the intestinal epithelium from enteric pathogens and toxins. It is used to assess gastrointestinal barrier function.

Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.

Immunoglobulin A (IgA) is an antibody playing a critical role in mucosal immunity and is produced in greater quantities than all other types of antibody combined.

In its secretory form, Secretory IgA is the main immunoglobulin found in mucous secretions and provides protection against potentially pathogenic microbes, due to its ability to resist degradation by enzymes and survive in harsh environments such as GI and respiratory tracts.

As the most abundant class of antibody found in the human intestinal lumen, secretory IgA (sIgA) is recognized as a first line of defense in protecting the intestinal epithelium from enteric pathogens and toxins. It is used to assess gastrointestinal barrier function.

Every mucosal membrane surface such as the eyes, nose, throat, and gastrointestinal system represent a large portal of entry for pathogenic bacteria, viruses, and yeasts. Secretory IgA (sIgA) is the predominant antibody found on these mucosal membranes, and represents the body’s first line of defense. SIgA levels change in response to stress.

The marker Sed Rate by Modified Westergren, also known as the erythrocyte sedimentation rate (ESR) or sedimentation rate, is a common blood test used by doctors to measure inflammation in the body, which is the natural response to injury or infection, often involving the immune system.

This test specifically looks at how quickly red blood cells settle to the bottom of a test tube over the course of one hour. The faster the red blood cells settle, the higher the sed rate, indicating potential inflammation.

Neutrophils are the most abundant type of white blood cell in the found. They are phagocytic, meaning that they engulf and destroy things like bacteria and viruses at the site of an injury. Like all other white blood cells, they also play a part in our body’s inflammatory response to things like allergens. 

Segmented neutrophils, often called “segs” or “segmenters,” are mature white blood cells that play a key role in fighting infections—especially bacterial infections. They are typically measured as part of a complete blood count (CBC) with differential and are reported as a percentage of total white blood cells or as an absolute count.

A normal range for segmented neutrophils is usually around 40–70%, although this can vary slightly by laboratory. Results should always be interpreted alongside your total white blood cell count, absolute neutrophil count (ANC), and other markers.

High segmented neutrophils (neutrophilia) are commonly seen with infections, inflammation, physical or emotional stress, smoking, or corticosteroid use. In most cases, mild elevations are temporary and resolve once the underlying cause improves.

Low segmented neutrophils may occur with viral infections, medication effects, bone marrow suppression, or certain autoimmune or nutritional conditions. Mild decreases are often not concerning, but persistently low levels—especially with a low ANC—may increase infection risk.

Because “segs,” “segmenters,” and “segmented neutrophils” are often used interchangeably on lab reports, understanding this marker can help you better interpret your CBC results and identify whether your immune system is responding to an active condition.