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Common and rare diseases — each with the biomarkers that define them.

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1 marker

B cell lymphoma

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1 marker

B-cell lymphoproliferative disorders

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8 markers

Bacterial Infection

Bacterial infections occur when harmful bacteria invade the body and multiply, triggering an immune response that can affect various organs and tissues. Common bacterial infections include pneumonia, urinary tract infections, skin and soft tissue infections like cellulitis, strep throat, and bacterial gastroenteritis. Symptoms typically include fever, localized pain or swelling, redness at the infection site, and general malaise, though presentation varies depending on which part of the body is affected. The immune system responds to bacterial infections by rapidly producing white blood cells to fight the invading pathogens, which can be detected through blood tests showing elevated infection markers. Diagnosis usually involves clinical evaluation, physical examination, and laboratory tests including blood work and cultures to identify the specific bacteria causing the infection. Treatment primarily consists of antibiotics targeted to the identified or suspected bacterial strain, along with supportive care such as rest, hydration, and pain management.

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4 markers

Bacterial Infections

Bacterial infections are caused by pathogenic bacteria—microscopic organisms capable of invading tissues, producing toxins, and triggering immune responses. Common examples include urinary tract infections (UTIs), strep throat, pneumonia, and foodborne illnesses such as salmonella. The body’s immune system plays a critical role in identifying and eliminating bacterial threats. However, factors such as weakened immunity, chronic disease, poor hygiene, or exposure to contaminated food, water, or surfaces can increase susceptibility. Symptoms depend on the site of infection but often include fever, chills, swelling, redness, pain, and fatigue. In systemic infections, symptoms may escalate to include rapid heart rate, confusion, or low blood pressure, indicating a more serious condition such as sepsis. Diagnosis typically involves clinical evaluation and laboratory testing, including blood tests, cultures, or biomarker analysis. Elevated markers such as white blood cell count (WBC), C-reactive protein (CRP), or procalcitonin may indicate an active bacterial infection.

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1 marker

Bacterial Meningitis

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1 marker

Bacterial Overgrowth

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1 marker

Basopenia

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2 markers

Basophilia

Basophilia: Understanding the Condition What is Basophilia? Basophilia, also known as basophilic disorder, occurs when your body produces an excessive number of basophils. Basophils are a type of white blood cell that plays a crucial role in your immune system by protecting your body from infections and responding to allergens. A high basophil count may indicate an infection, or it could be a sign of more serious conditions like leukemia or autoimmune diseases. Normally, basophil levels range from 0 to 300 basophils per microliter of blood, or less than 2% of total white blood cells. Basophilia is relatively rare, occurring in less than 1% of the general population. Causes of Basophilia Basophilia happens when there is an unusually high number of basophils in your blood. This can be caused by various factors, including: - Myeloproliferative Disorders: These are conditions where the bone marrow produces too many blood cells. Examples include chronic myelogenous leukemia (CML), primary myelofibrosis, and essential thrombocythemia.

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2 markers

Benign prostatic hyperplasia (BPH)

Benign Prostatic Hyperplasia (BPH): Symptoms, Diagnosis, and Treatment Guide for Prostate Enlargement Benign Prostatic Hyperplasia (BPH), also known as prostate gland enlargement, is one of the most common conditions affecting men as they age. This in-depth guide covers BPH symptoms, diagnosis methods, and treatment options to help you understand and manage this condition effectively. Whether you're searching for early signs of BPH or looking for the best treatments for enlarged prostate, this article provides everything you need to know. What is Benign Prostatic Hyperplasia (BPH)? Benign Prostatic Hyperplasia (BPH) refers to the non-cancerous enlargement of the prostate gland. The prostate is a small gland located below the bladder, surrounding the urethra—the tube that carries urine out of the body. As men age, the prostate often grows larger, leading to urinary problems due to its position near the bladder and urethra. How Common is BPH? BPH affects approximately 50% of men over 50. By age 80, up to 90% of men experience some degree of prostate enlargement.

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1 marker

Beta Thalassemia

Beta Thalassemia is a genetic blood disorder that affects the body's ability to produce hemoglobin, the protein in red blood cells responsible for carrying oxygen throughout the body. This condition is caused by mutations in the HBB gene on chromosome 11, which leads to reduced or absent production of beta-globin, one of the two subunits of hemoglobin. Beta Thalassemia is inherited in an autosomal recessive pattern, meaning a person must inherit two mutated genes (one from each parent) to be affected by the condition. There are several forms of Beta Thalassemia, ranging from mild to severe, based on the mutations' effects on hemoglobin production. The mildest form is known as Beta Thalassemia minor or Beta Thalassemia trait, where individuals often experience little to no symptoms and may not even be aware they carry the gene mutation. More severe forms include Beta Thalassemia intermedia and Beta Thalassemia major, also known as Cooley's anemia.

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1 marker

Biliary Obstruction

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Bipolar disorder

Understanding Bipolar Disorder: Symptoms, Diagnosis, and Treatment Bipolar disorder is a mental health condition characterized by extreme mood swings that include emotional highs (mania or hypomania) and lows (depression). These mood shifts can affect sleep, energy, activity, judgment, behavior, and the ability to think clearly. Bipolar disorder is a lifelong condition, but with proper management, individuals can lead fulfilling lives. Understanding the symptoms, diagnostic methods, and treatment options is crucial for effective management of this disorder. Symptoms of Bipolar Disorder The symptoms of bipolar disorder are divided into two main types: manic/hypomanic episodes and depressive episodes. During a manic episode, individuals may feel euphoric, full of energy, or unusually irritable. They may engage in risky behaviors, have racing thoughts, speak rapidly, and require less sleep. Hypomania is a less severe form of mania that does not cause significant impairment in social or occupational functioning.

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1 marker

Bladder Cancer

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3 markers

Bone Marrow Disorders

Bone marrow disorders are a group of conditions that affect the production and development of blood cells within the bone marrow—the soft, spongy tissue found inside bones responsible for generating red blood cells, white blood cells, and platelets. When bone marrow function is disrupted, it can lead to abnormalities in one or more of these cell lines, resulting in a wide range of clinical consequences, from mild cytopenias to life-threatening hematologic disease. These disorders include conditions such as anemia (including aplastic anemia), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPNs), leukemia, and bone marrow infiltration from cancers or fibrosis (myelofibrosis). Depending on the underlying cause, bone marrow disorders may involve underproduction, overproduction, or dysfunctional development of blood cells. At the biological level, bone marrow disorders often arise from abnormalities in hematopoietic stem cells—the precursor cells that give rise to all blood cell types.

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1 marker

Bone Marrow Stress / Recovery

Bone marrow stress or recovery refers to the bone marrow's response to conditions that either suppress blood cell production or require increased production to meet the body's demands, often resulting in temporary changes in blood cell counts and the release of immature cells into circulation. Bone marrow stress can be caused by chemotherapy or radiation therapy (which damage rapidly dividing cells including bone marrow), severe infections that deplete the body's reserves of infection-fighting cells, significant blood loss requiring rapid red blood cell replacement, nutritional deficiencies (such as vitamin B12, folate, or iron deficiency), certain medications that suppress bone marrow function, and autoimmune conditions where the immune system attacks blood-forming cells. During the recovery phase, the bone marrow rebuilds its reserves and may temporarily release immature blood cells into circulation as production accelerates, which is often enhanced by medications called growth factors (such as G-CSF, erythropoietin, or thrombopoietin) that stimulate specific blood cell lines.

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1 marker

Bone Marrow Suppression

What Is Bone Marrow Suppression? Bone marrow suppression is a condition in which the bone marrow produces fewer blood cells than normal. This can affect red blood cells, white blood cells, and platelets, leading to a range of symptoms depending on which cell lines are most impacted. In more severe cases, this can result in Pancytopenia, where all three major blood cell types are reduced. Because these cells are essential for carrying oxygen, fighting infections, and helping blood clot, bone marrow suppression can affect many systems in the body. What Happens in the Body The bone marrow is responsible for continuously producing new blood cells from hematopoietic stem cells. In bone marrow suppression, this process slows down or becomes less effective. As a result: Fewer red blood cells are produced, reducing oxygen delivery to tissues Fewer white blood cells are produced, weakening the immune response Fewer platelets are produced, increasing bleeding risk The degree of suppression can vary from mild and temporary to severe and life-threatening.

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1 marker

Bone Metastases

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1 marker

Breast Cancer

Breast cancer is a malignant condition characterized by the uncontrolled growth of cells within breast tissue — most commonly originating in the ducts (ductal carcinoma) or lobules (lobular carcinoma). It is the most common cancer in women worldwide and a leading cause of cancer-related mortality, though outcomes have improved significantly with early detection and advances in treatment. Breast cancer is not a single disease but a biologically diverse group of tumors with distinct molecular subtypes, risk profiles, and treatment responses. These differences are largely defined by the presence or absence of hormone receptors (estrogen and progesterone) and HER2 expression, which guide both prognosis and therapy. Early identification through screening and prompt diagnostic evaluation is critical, as breast cancer is highly treatable — and often curable — when detected at an early stage. How Breast Cancer Develops Normal breast cells grow and divide in a regulated manner.

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