Citrulline is an intermediate, nonprotein-forming amino acid in the urea cycle serving as a precursor to arginine. It derives its name from the watermelon (Citrullus vulgaris), where it was first isolated and identified. It is easily absorbed by the gut and bypasses the liver, making it an effective method for repleting arginine.

Other food sources of citrulline include muskmelons, bitter melons, squashes, gourds, cucumbers and pumpkins. Citrulline can also be synthesized from arginine and glutamine in enterocytes, which can then be metabolized by the kidneys back into arginine. Because citrulline is produced in enterocytes, it has been proposed as a marker of enterocyte mass in conditions of villous atrophy.

→ Citrulline comes from dietary sources and plasma amino acid precursors such as arginine, ornithine, glutamine, glutamate, or proline.

→ Enterocytes are the main site of citrulline production, making small intestine function a key determinant of plasma citrulline levels.

→ Decreased blood citrulline was associated with impaired enterocyte function and small bowel absorptive capacity, increased risk of diabetes, a marker of physical frailty and sarcopenia, and multiple sclerosis.

Citrulline is an amino acid that is not one of the essential amino acids nor a common dietary amino acid (named after its only good natural source, watermelons), but is interconverted in the body and serves roles similar to L-arginine and L-ornithine.

Common food sources:

Food sources of L-citrulline include watermelon, muskmelons, bitter melons, squashes, gourds, cucumbers, and pumpkins.

The amino acid citrulline gets its name from its high concentration in the watermelon Citrullus vulgaris. In human kidneys, citrulline and aspartic acid are united by argininosuccinate synthetase (ASS) to produce arginosuccinate. The degradation of arginosuccinate to fumarate and arginine is a primary mechanism for sustaining plasma levels of arginine. The same enzyme acts in liver cells to complete the urea cycle.

There are three types of Creatine Kinase enzymes:

CK-MM, found mostly in skeletal muscles
CK-MB, found mostly in the heart muscle
CK-BB, found mostly in your brain. It's also found in smooth muscles such as the intestine or uterus.

A small amount of CK in the blood is normal. Higher amounts can mean a health problem. Depending on the type and level of CK found, it can mean you have damage or disease of the skeletal muscles, heart, or brain.

Creatine Kinase is a type of protein that is mostly found in the skeletal muscle (CK-MM). 97 to 100% of Creatine Kinase are usually found in skeletal muscle. The other two types of Creatine Kinase are CK-MB (Creatine Kinase found in the heart muscle) and CK-BB (Creatine Kinase found in brain tissue).

There are three types of Creatine Kinase enzymes:

CK-MM, found mostly in skeletal muscles
CK-MB, found mostly in the heart muscle
CK-BB, found mostly in brain tissue

CK-MB isoenzymes level helps quantify the degree of myocardial infarction and the timing of onset of infarction.

This enzyme is also used to determine the effectiveness of thrombolytic therapy used for myocardial infarction.

This is found in cardiac and skeletal muscles. The cardiac muscle has 30%, and the skeletal muscle has 1% MB.

Creatine Kinase is a type of protein that is mostly found in the skeletal muscle (CK-MM). 97 to 100% of Creatine Kinase are usually found in skeletal muscle. The other two types of Creatine Kinase are CK-MB (Creatine Kinase found in the heart muscle) and CK-BB (Creatine Kinase found in brain tissue).

There are three types of Creatine Kinase enzymes:

CK-MM, found mostly in skeletal muscles
CK-MB, found mostly in the heart muscle
CK-BB, found mostly in brain tissue

A small amount of CK in the blood is normal. Higher amounts can mean a health problem. Depending on the type and level of CK found, it can mean you have damage or disease of the skeletal muscles, heart, or brain

Cladosporium, a well known trigger for asthmatic attacks, is one of the most widespread molds.

Cladosporium includes about 40 species naturally found in soil, on decaying plant material and as plant pathogens. 

In an indoor environment, Cladosporium spp. occur as secondary wall colonizers, appearing after the primary ones such as Penicillium species, Aspergillus versicolor and Wallemia sebi. Cladosporiumis very common on wet building material (e.g., gypsum board, acrylic painted walls, wood, wallpaper, carpet and mattress dust, HVAC fans, and wet insulation in mechanical cooling units).

Cladosporium, a well known trigger for asthmatic attacks, is one of the most widespread molds.

Cladosporium includes about 40 species naturally found in soil, on decaying plant material and as plant pathogens. 

In an indoor environment, Cladosporium spp. occur as secondary wall colonizers, appearing after the primary ones such as Penicillium species, Aspergillus versicolor and Wallemia sebi. Cladosporiumis very common on wet building material (e.g., gypsum board, acrylic painted walls, wood, wallpaper, carpet and mattress dust, HVAC fans, and wet insulation in mechanical cooling units).

Cladosporium, a well known trigger for asthmatic attacks, is one of the most widespread molds.

Cladosporium includes about 40 species naturally found in soil, on decaying plant material and as plant pathogens. 

In an indoor environment, Cladosporium spp. occur as secondary wall colonizers, appearing after the primary ones such as Penicillium species, Aspergillus versicolor and Wallemia sebi. Cladosporiumis very common on wet building material (e.g., gypsum board, acrylic painted walls, wood, wallpaper, carpet and mattress dust, HVAC fans, and wet insulation in mechanical cooling units).

Cladosporium, a well known trigger for asthmatic attacks, is one of the most widespread molds.

Cladosporium includes about 40 species naturally found in soil, on decaying plant material and as plant pathogens. 

In an indoor environment, Cladosporium spp. occur as secondary wall colonizers, appearing after the primary ones such as Penicillium species, Aspergillus versicolor and Wallemia sebi. Cladosporiumis very common on wet building material (e.g., gypsum board, acrylic painted walls, wood, wallpaper, carpet and mattress dust, HVAC fans, and wet insulation in mechanical cooling units).

Elevated antibody levels can be clinically significant — while the antibodies themselves don’t destroy anything, they do trigger an inflammatory response that can cause significant destruction of tissue and resulting symptoms. This response is not necessarily dependent on antibody levels. However, an equivocal result may mean you are just beginning to exhibit an immune reaction, so this is an important time to take measures to support the body in damping immune reactivity.