Total Immunoglobulins
Performed by: Vibrant America
This panel evaluates the levels of four key antibody types—IgG, IgA, IgM, and IgE—providing a comprehensive overview of immune system function. It aids in identifying immune deficiencies, chronic infections, autoimmune conditions, and allergic responses. Monitoring these immunoglobulins is particularly beneficial for individuals experiencing recurrent infections, unexplained inflammation, or undergoing immunosuppressive therapy.
IgG (Immunoglobulin G)
What it measures:
IgG is the most abundant antibody in the body and plays a key role in long-term immunity. It is produced during later stages of an infection and remains in circulation to provide lasting protection.
High IgG levels may indicate:
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Chronic infections (e.g., hepatitis, HIV)
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Autoimmune diseases (e.g., lupus, rheumatoid arthritis)
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Multiple myeloma or other gammopathies
Low IgG levels may indicate:
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Immunodeficiency disorders (e.g., Common Variable Immunodeficiency)
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Poor immune function or malnutrition
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Protein-losing conditions (e.g., nephrotic syndrome)
Why it matters:
Low IgG can lead to frequent infections, while high IgG may point to chronic immune activation or malignancy.
IgA (Immunoglobulin A)
What it measures:
IgA is primarily found in mucosal areas such as the respiratory and gastrointestinal tracts. It helps protect against pathogens that enter through mucosal surfaces.
High IgA levels may indicate:
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Chronic liver disease (e.g., cirrhosis)
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Inflammatory bowel disease (e.g., ulcerative colitis, Crohn’s disease)
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Autoimmune disorders (e.g., celiac disease, lupus)
Low IgA levels may indicate:
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Selective IgA deficiency (a common immunodeficiency)
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Increased susceptibility to respiratory and digestive infections
Why it matters:
Abnormal IgA levels can impact your ability to fight off infections and may signal gut or autoimmune disorders.
IgM (Immunoglobulin M)
What it measures:
IgM is the first antibody produced in response to an infection. It acts as a front-line defense during the initial immune response.
High IgM levels may indicate:
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Acute or recent infections
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Waldenström’s macroglobulinemia
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Certain autoimmune diseases (e.g., primary biliary cholangitis)
Low IgM levels may indicate:
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Immunodeficiencies
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Bone marrow suppression or genetic disorders
Why it matters:
IgM levels help differentiate between early-stage and long-term immune responses, offering insight into how your body is responding to infections.
IgE (Immunoglobulin E)
What it measures:
IgE is involved in allergic responses and defense against parasites. It binds to allergens and triggers the release of histamine from mast cells.
High IgE levels may indicate:
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Allergies (e.g., pollen, food, dust mites)
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Asthma or eczema
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Parasitic infections
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Atopic dermatitis
Low IgE levels are usually not clinically significant, but may be evaluated in conjunction with other immune markers.
Why it matters:
Elevated IgE is a key marker for allergic disease and may help guide treatment strategies for asthma, eczema, or food sensitivities.
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Biomarkers included in this panel:
What is Total IgA? Total IgA measures the concentration of Immunoglobulin A in the blood, an antibody that plays a crucial role in immune defense—particularly in the mucous membranes of the respiratory, gastrointestinal, and urogenital tract
Learn moreWhat is Total IgG? Total IgG measures the concentration of Immunoglobulin G, the most abundant antibody in the bloodstream. IgG plays a central role in long-term immune protection by recognizing and neutralizing viruses, bacteria, and other foreig
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