Complete Hormones FMV - Menopause Female
Urine
Performed by: Genova Diagnostics
Complete Hormones is Genova's most comprehensive urinary hormone profile, and is designed to assist with the clinical management of hormone-related symptoms in both male and females. This profile assesses parent hormones and their metabolites as well as key metabolic pathways, provides insight into the contribution that sex hormones may have in patients presenting with hormone-related complaints, and helps assess disease risk associated with elevated estrogen metabolites.
Urine measures the most metabolites, providing more insight into associated disease risk.
The Complete Hormones profile evaluates:
- Progesterone (via pregnanediol)
- Glucocorticoids, including cortisol
- Androgens, including DHEA and testosterone, and their metabolites
- Estrogens (E1 Estrone, E2 Estradiol, E3 Estriol) and metabolites, including hydroxylated and methoxylated estrogens
- Methylation capacity
- 5α-reductase activity
- Anabolic/Catabolic Balance
When should the Complete Hormones test be considered?
The Complete Hormones test is designed to assist in the management of hormone-related symptoms in both males and females.
The Complete Hormones test is ideal for establishing a baseline assessment of parent hormones and their metabolites ahead of clinical intervention with hormone therapy (HT) as well as subsequent monitoring if needed in both female and male patients.
The Complete Hormones test provides insight into the impact that shifting hormone levels may play in men (andropause or male menopause) and women (peri/menopause). Symptoms include the following:
- Weight gain
- Anxiety
- Fatigue
- Muscle mass loss
- Muscle weakness
- Low libido and sexual performance issues
- Hair loss
- Sleep disturbances
- Brain fog
- Mood instability
- Hot flashes
- Vaginal dryness
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Biomarkers included in this panel:
11-Hydroxy-androsterone is a 5β-reduced compound that is an end product of androgen catabolism. In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group. Androgens are important hormones in the
Learn more11-Hydroxy-etiocholanolone is a compound that is an end product of androgen catabolism. In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group. Androgens are important hormones in the health
Learn more11-Keto-androsterone is a that is an end product of androgen catabolism. In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group. Androgens are important hormones in the health of both men and
Learn more11-Keto-etiocholanolone is a 5β-reduced compound that is an end product of androgen catabolism. In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group. Androgens are important hormones in the
Learn more16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-trien-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estri
Learn moreAn elevated 17-hydroxysteroids total and/or cortisol total may be caused by stress, strenuous exercise, inflammation, hypoglycemia, insulin resistance, hypothyroidism, or licorice ingestion.
Learn moreANDROGENS such as DHEA, testosterone, and androstenedione tend to be extensively metabolized into downstream androgen compounds. As a result, the levels of testosterone along with “Total 17-ketosteroids” (DHEA plus metabolites) should be
Learn moreAn elevated 17-hydroxysteroids total and/or cortisol total may be caused by stress, strenuous exercise, inflammation, hypoglycemia, insulin resistance, hypothyroidism, or licorice ingestion.
Learn moreTestosterone and DHEA are metabolized into what are collectively known as the 17-ketosteroids.
Learn moreThere is evidence that methoxylated estrogens, especially the 2-pathway methoxylated estrogens (E1 and E2), are associated with decreased breast cancer risk; 2-MeOE2, produced from 2-OHE2, has been described to have anti-proliferative, antingiogenic,
Learn moreResearch focus is shifting toward 4-hydroxyesterone which is thought to have greater estrogenic and genotoxic potential than either 2-hydroxyestrone or 16a-hydroxyestrone.
Learn moreMost recent studies find an increased breast cancer risk associated with the ratio of 4-pathway cetechols to 4-pathway methylated catechols.
Learn moreThis marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.
Learn moreThe Anabolic/Catabolic Balance refers to the balance between "growth and healing" (anabolic) and "wear and tear" (catabolic) activity in the body. Both anabolic and catabolic metabolism are essential to health.
Learn moreThe measurement of androstanediol, in addition to testosterone, is of interest for the evaluation of androgenic activity.
Learn moreAndrosterone and Etiocholanolone are DHEA metabolites via Androstenedione and the 5α- and 5β-reductase pathways.
Learn moreDHEA is a hormone produced by both the adrenal gland and the brain. DHEA leads to the production of androgens and estrogens. DHEA levels in the body begin to decrease after age 30. Levels decrease more quickly in women.
Learn moreThe Etiocholanolone/Androsterone (E/A) Ratio assesses androgen metabolism by comparing the enzymatic activity of 5β-reductase/5α-reductase.
Learn moreThe most physiologically active estrogen. Binds to both to ER and Estrogen Receptor Beta (ERβ). Estradiol, made in the ovary, rapidly converts to estrone. Poor symptom control with estrogen replacement may suggest the need for improving abs
Learn moreHas weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.
Learn moreProduced by the ovaries, the estrone hormone is one of three types of estrogen, and it is one of the major hormones found in the bodies of postmenopausal women. While research into estrone function is still ongoing, since it is the least powerful of
Learn moreEtiocholanolone is an androstenedione and testosterone metabolite that is excreted in the urine. It is produced from androstenedione and the 5-alpha and 5-beta-reductase metabolic pathways. It is helpful in evaluating adrenal and androgen function.
Learn moreProgesterone rapidly metabolizes by the time it reaches the urine, and its direct metabolite, pregnanediol, is a reflection of circulating progesterone concentrations.
Learn moreProgesterone is metabolized into numerous downstream compounds, but most immediately into pregnanediol and pregnanetriol. Urine levels of these metabolites tend to correlate with levels of serum progesterone, thus may be used to assess status of the
Learn moreTestosterone is the major androgen in the body. It is converted to dihydrotestosterone by 5-alphareductase, and to estradiol by aromatase.
Learn moreThis marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.
Learn moreThis marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.
Learn moreThis marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.
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