Celiac Comprehensive Panel
Blood Serum
Celiac Comprehensive Panel
A Comprehensive Celiac Panel is a set of blood tests used to screen for and help diagnose celiac disease—an autoimmune disorder triggered by gluten, the protein found in wheat, barley, and rye. In people with celiac disease, the immune system mistakenly attacks the lining of the small intestine. Over time, this can cause intestinal damage, poor nutrient absorption, digestive upset, anemia, fatigue, and other health problems.
What this panel measures
This panel combines several antibody and immune markers to improve accuracy and reduce false negatives:
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Tissue Transglutaminase IgA (tTG-IgA): The most common and sensitive screening test for celiac disease. Elevated levels strongly suggest an autoimmune response to gluten.
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Tissue Transglutaminase IgG (tTG-IgG): Useful for individuals with IgA deficiency, a condition that can otherwise mask celiac disease.
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Deamidated Gliadin Peptide (DGP) IgA and IgG: Detect immune responses against gluten-derived proteins. Helpful in children and when tTG results are inconclusive.
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Endomysial Antibody (EMA-IgA): Highly specific for celiac disease and often used to confirm a diagnosis.
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Total Serum IgA: Measures overall IgA levels. Since IgA deficiency can cause false negatives, this test ensures the reliability of other antibody results.
Why a comprehensive panel matters
Relying on a single test can miss cases of celiac disease. Using a combination of markers provides:
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A more accurate picture of immune activity
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Reduced risk of false negatives
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Broader insights into gluten sensitivity and intestinal health
Clinical relevance
When celiac disease goes undiagnosed, it can lead to long-term complications such as nutrient deficiencies, osteoporosis, infertility, neurological problems, and an increased risk of certain cancers. Early detection through a comprehensive panel allows for timely treatment—most often adopting a strict gluten-free diet—to help restore gut health and prevent complications.
Note: While blood tests are powerful tools for detecting celiac disease, confirmation with an intestinal biopsy is often recommended by healthcare providers.
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Biomarkers included in this panel:
Anti-gliadin IgA is an important antibody in the context of diagnosing celiac disease, an autoimmune disorder that affects the small intestine. When individuals with celiac disease consume gluten—a protein found in wheat, barley, and rye—
Learn moreAnti-gliadin IgG is an antibody that the immune system produces in response to gliadin, a component of gluten found in wheat, barley, and rye. When someone with a sensitivity to gluten consumes these grains, their immune system may mistakenly identif
Learn moreDeamidated gliadin peptide (DGP) antibodies, measured as IgA or IgG (anti-DGP), are blood tests used in the evaluation of suspected celiac disease. These antibodies help detect an abnormal immune response to gluten and are particularly useful in situ
Learn moreDetection of gliadin antibodies aids in the diagnosis and monitoring of certain gluten-sensitive enteropathies, such as celiac disease and dermatitis herpetiformis.
Learn moreDGP IGA
The Deamidated Gliadin Peptide Immunoglobulin A (DGP IGA) marker plays a pivotal role in the celiac disease diagnostic process, offering unique insights that complement other testing methods in a celiac panel. This test specifically measures the IGA
Learn moreDQ2
Celiac disease is a chronic immune-mediated inflammatory disorder with multi-systemic manifestations, both gastrointestinal and nongastrointestinal. In genetically susceptible individuals, ingestion of gluten can cause inflammation and damage to the
Learn moreDQ8
Celiac disease is a chronic immune-mediated inflammatory disorder with multi-systemic manifestations, both gastrointestinal and nongastrointestinal. In genetically susceptible individuals, ingestion of gluten can cause inflammation and damage to the
Learn moreEndomysial Antibody IgA
This test looks for certain antibodies in your blood that may mean you have celiac disease, an autoimmune disease. Presence of the tissue transglutaminase (tTG) IgA antibody is associated with gluten-sensitive enteropathies such as celiac disease
Learn moreThe "Endomysial Antibody Screen (IgA) with Reflex to Titer" is a specific blood test often used to help diagnose celiac disease, an autoimmune disorder where the ingestion of gluten leads to damage in the small intestine. This test looks fo
Learn moreThe Endomysial Antibody Titer is a crucial diagnostic tool in the evaluation of celiac disease and related gluten-related disorders, aiding in early diagnosis and appropriate management.
Learn moreA tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease or to see how well people with the condition are doing.
Learn moreA tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease or to see how well people with the condition are doing.
Learn moreTTG IGA
The TTG IGA marker is a crucial element in the diagnostic process for celiac disease, offering a high degree of accuracy in identifying this autoimmune disorder. Tissue Transglutaminase (TTG) is an enzyme targeted by the immune system in celiac disea
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