Bile Acids, Fractionated LCMS
Serum Plasma
Performed by: LabCorp
The Bile Acids, Fractionated LC-MS test offered by Labcorp is a specialized diagnostic assay that utilizes liquid chromatography-mass spectrometry (LC-MS) to measure and profile various bile acids in a patient's biological sample, typically serum or plasma. This test is primarily used to assess liver function, diagnose cholestasis, and monitor metabolic disorders related to bile acid synthesis and transport.
Key Features of the Test
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Advanced Analytical Technique: LC-MS provides high specificity and sensitivity, enabling the detection of both primary and secondary bile acids, as well as conjugated and unconjugated forms.
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Comprehensive Profiling: The test measures a broad spectrum of bile acids, including but not limited to cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid, and ursodeoxycholic acid.
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Clinical Applications:
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Evaluation of cholestatic liver diseases such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).
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Assessment of inborn errors of bile acid synthesis.
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Monitoring of patients undergoing bile acid sequestrant therapy.
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Investigation of unexplained liver enzyme elevations.
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Interpretation of Results: The test results are typically interpreted by healthcare providers in conjunction with clinical findings and other laboratory tests to provide a comprehensive understanding of the patient's condition.
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Biomarkers included in this panel:
Chenodeoxycholic Acid on Labcorp's Bile Acids, Fractionated LC/MS-MS Panel Chenodeoxycholic acid is a primary bile acid synthesized in the liver from cholesterol, playing a crucial role in the digestion and absorption of fats and fat-soluble v
Learn moreCholic acid is a primary bile acid synthesized in the liver from cholesterol. It plays a crucial role in the emulsification and absorption of dietary fats and fat-soluble vitamins in the small intestine. Cholic acid is also involved in regulating cho
Learn moreDeoxycholic Acid on Labcorp's Bile Acids, Fractionated LC/MS-MS Panel Deoxycholic acid is a secondary bile acid formed in the colon by the bacterial metabolism of primary bile acids, such as cholic acid. On Labcorp's Bile Acids, Fractionat
Learn moreTotal bile acids refer to the sum of all bile acids present in the bloodstream, including both primary and secondary bile acids. On Labcorp's Bile Acids, Fractionated LC/MS-MS Panel, the measurement of total bile acids provides a comprehensive as
Learn moreUrsodeoxycholic acid (UDCA) is a naturally occurring bile acid that has been extensively studied and utilized in the treatment of various liver and gallbladder conditions. It is particularly effective in managing cholestatic liver diseases, where bil
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