Cytokine assay panel for immune profile
Serum
Performed by: SYNLAB
Cytokines are a large group of secreted proteins with diverse structures and functions, which regulate and coordinate many cells activities of innate and adaptive immune systems. Therefore, these molecules are involved in multiple processes: acute inflammations such as infectious or post-vaccinal conditions, chronic inflammations such as autoimmune diseases, chronic infections or tumors.
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Biomarkers included in this panel:
CCL3, also known as Macrophage Inflammatory Protein-1 alpha (MIP-1α), is a chemokine protein that plays a critical role in the immune response and inflammation. Chemokines are small proteins that act as signaling molecules, attracting and direc
Learn moreCCL4 is a chemoattractant for critical immune regulatory cells such as monocytes/macrophages, T-lymphocytes, natural killer cells and dendritic cells. CCL4 is produced by monocytes, T/B lymphocytes, neutrophils, fibroblasts and endothelial/epithel
Learn moreT-Cell-Specific Protein RANTES is chemotactic for T-cells, human eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. It also activates the release of proteins from eosinophils such as eosinophilic cati
Learn moreIFN-γ is a helper T-cell 1 (Th1)-derived cytokine and plays a critical role for both innate and adaptive immunity against viral and intracellular bacterial infections and tumor control.
Learn moreGM-CSF stands for Granulocyte-Macrophage Colony-Stimulating Factor. It is a protein that functions as a growth factor and cytokine in the immune system. GM-CSF is produced by various cells, including immune cells like T cells, macrophages, and endoth
Learn moreInterleukin-10 is an important suppressor of immune responses. In vitro studies indicate that Interleukin-10 directly inhibits IL-2 and IL-5 production by TH1 and TH2 cells. Interleukin-10 acts as an immunosuppressor of antigen presenti
Learn moreInterleukin 13 is a mediator of allergic inflammation and different diseases including asthma. IL-13 is implicated in numerous processes, including a) recruitment of eosinophils and M2 macrophages to the lung, b) induction of mucus secretion into
Learn moreInterleukin 2 is a pleiotropic cytokine produced primarily by mitogen- or antigen- activated T lymphocytes. Interleukin 2 plays a role in promoting the clonal expansion of antigen-specific cytotoxic and suppressor T cells. In vitro studi
Learn moreInterleukin 4 is a pleiotropic cytokine produced by activated T lymphocytes, CD3+ cells, NK-T cells, mast cells, eosinophils, and basophils. Interleukin 4 has multiple immune response modulation functions on a variety of cell types. It
Learn moreInterleukin-6 is involved in inflammation and infection responses and also in the regulation of metabolic, regenerative, and neural processes.
Learn moreInterleukin 8 (IL-8) is a promising marker for many clinical conditions and currently being applied by various subspecialties of medicine either for the purpose of rapid diagnosis or as a predictor of prognosis. Nevertheless, IL-8 level increased as
Learn moreCD40 ligand (CD40L), also known as CD154, is a protein that is primarily expressed on the surface of activated T cells and belongs to a member of the tumor necrosis factor superfamily. Lack of CD40L results in an inability to undergo immunoglobulin c
Learn moreResults are used to understand the pathophysiology of immune, infectious, or inflammatory disorders, or may be used for research purposes. Tumor necrosis factor-α (cachectin) and tumor necrosis factor-β (lymphotoxin) are two closely rel
Learn moreWhat is the VEGF test? This test measures the amount of vascular endothelial growth factor (VEGF) in your blood. VEGF is a substance that helps encourage the growth of new blood vessels. Your body makes more VEGF in certain cases. For instance, if
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