Organix Comprehensive Profile - Urine
Urine
Performed by: Genova Diagnostics
The Organix Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes.
Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth.
The Organix Comprehensive nutritional test profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:
- Functional vitamin and mineral status
- Amino acid insufficiencies like carnitine and NAC
- Oxidative damage and antioxidant need
- Phase I & Phase II detoxification capacity
- Functional B-complex vitamin need
- Neurotransmitter metabolites
- Mitochondrial energy production
- Methylation sufficiency
- Lipoic acid and CoQ10 status
- Markers for bacterial and yeast overgrowth
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Biomarkers included in this panel:
2-Methylhippurate is a byproduct of detoxification of the common solvent xylene. Urinary excretion of 2-methylhippurate is a sensitive and specific marker for xylene exposure which increases oxidative stress.
Learn more3,4-Dihydroxyphenylpropionate seems to be strongly associated with a troublesome type of bacteria called Clostridia.
Learn more3-Hydroxybutyric acid is a typical partial-degradation product of branched-chain amino acids (primarily valine) released from muscle for hepatic and renal gluconeogenesis. This acid is metabolized by 3-hydroxybutyrate dehydrogenase. The enzyme f
Learn more5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels
Learn more8-hydroxy-2-deoxyguanosine measures the oxidative impact to DNA. 8-hydroxy-2-deoxyguanosine levels will be high if your total antioxidant protection is inadequate.
Learn moreAdipate, together with Suberate and Ethylmalonate are all functional markers for deficiency of carnitine.
Learn moreAlpha-Hydroxybutyrate is a by-product of glutathione production. Levels of alpha-hydroxybutyrate in the urine may reflect levels of glutathione production.
Learn moreAlpha-Keto-Beta-Methylvalerate is a B-Complex Vitamin Marker. Vitamins are compounds that your body needs to be healthy. Vitamins are “essential” for proper function, which means that they are not made inside your body and
Learn moreAlpha-Ketoglutarate is an organic acid that is important for the proper metabolism of all essential amino acids. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells.
Learn moreAlpha-Ketoisocaproate is a B-Complex Vitamin Marker (Leucine catabolism).
Learn moreAlpha-Ketoisovalerate (together with Alpha-Ketoisocaproate and Alpha-Keto-Beta-methylvalerate) requires Vitamins B1, B2, B3, B5 and lipoic acid to be metabolized.
Learn moreBenzoate, was one of the compounds first found to be elevated in urine from patients with intestinal bacterial overgrowth of various origins.
Learn moreß-Hydroxybutyrate is a metabolic marker of blood sugar utilization and insulin function.
Learn moreBeta-Hydroxyisovalerate is a sensitive indicator of biotin deficiency and is a metabolite of the amino acid isoleucine.
Learn morecis-Aconitate is involved in both energy production and removal of toxic ammonia.
Learn moreCitric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells.
Learn moreD-Arabinitol is a marker for intestinal yeast overgrowth. Yeast is another class of microbes that can chronically grow in the intestinal tract and cause adverse health effects through the release of toxic metabolites. D-Arabinitol is uniquely
Learn moreD-Lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. This by-product is excreted in the urine.
Learn moreEthylmalonate, together with Adipate and Suberate, gives information about your ability to process fatty acids.
Learn moreFormiminoglutamate (FIGLU) is a functional marker of insufficiency of folic acid, another B-vitamin, and is a compound made from the amino acid histidine.
Learn moreFumarate (together with Succinate and Malate) is used in the body’s metabolic pathway that generates cellular energy – the Citric Acid Cycle.
Learn moreGlucarate helps your liver perform its important role in removing from your body many types of toxins such as pesticides, prescription drugs, food components, and intestinal bacteria.
Learn moreMicrobes resident in the large intestine of the human body help to break down complex aromatic compounds in dietary plant matter (polyphenols), freeing up benzoic acid, which enters the bloodstream. The liver can add the amino acid glycine to benzoic
Learn moreHistamine is a compound that affects immune response and physiological function of the digestive tract, and also acts as a neurotransmitter. Histamine helps control the sleep-wake cycle as well as energy and moti
Learn moreHomovanillate (aka Homovanillic Acid) is a dopamine metabolite. Homovanillate and Vanilmandelate are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.
Learn moreHydroxymethylglutarate (HMG) is the precursor to Coenzyme Q10 (CoQ10) production, and when it is elevated it may indicate that the body is trying to increase its production of CoQ10.
Learn moreIndican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine.
Learn moreCitric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells.
Learn moreAlpha-Ketoisovalerate requires Vitamin B1, B5, lipoic acid, B2, and B3 (in descending order of significance) to be metabolized. As your food is broken down, specific compounds are formed at steps that require B vitamin assistance. a-Ketoiso
Learn moreKynurenate is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein.
Learn moreL-Lactate is a product of muscle use, so it is constantly produced in normal daily activity.
Learn moreMalate is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism.
Learn moreMethylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
Learn moreOrotate is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supp
Learn moreThe presence of organic compounds such as p-Hydroxybenzoate in the urine may point towards significant dysbiosis (=impaired microbiota).
Learn moreAssociated with small intestinal bacteria overgrowth (SIBO) due to its production by C. di cile, C. stricklandii, C. lituseburense, C. subterminale, C. putrefaciens, and C. propionicum.
Learn morep-hydroxyphenyllactate is a marker of cell turnover. It is also a metabolite in tyrosine degradation and may be useful for studying disorders of tyrosine metabolism.
Learn moreProduced from bacterial degradation of unabsorbed phenylalanine.
Learn morePhenylpropionate is a intestinal microbial balance marker. Phenylpropionate is formed from bacterial action on phenylalanine and it should only be present at very low levels.
Learn morePicolinate is a neurotransmitter metabolism marker and is produced under inflammatory conditions.
Learn morePyroglutamate (or Pyroglutamic acid) is an intermediate in the glutathione metabolism and a marker of glutathione deficiency.
Learn morePyruvate feeds into the citric acid cycle & converts into acetyl CoA. Pyruvate is formed from carbohydrate via glucose or glycogen & secondarily from fats (glycerol) & glycogenic amino acids.
Learn moreQuinolinic acid is a neurotoxic substance produced by our own bodies and a metabolite of tryptophan.
Learn moreSuberate, Adipate, and Ethylmalonate elevations can indicate that you may need additional carnitine and/or vitamin B2 to assist your cells in converting fats into energy efficiently.
Learn moreSuccinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body.
Learn moreSulfate is associated with your body’s use of glutathione, an amino acid critical for removing toxins that is also a powerful antioxidant.
Learn moreTricarballylate is produced by a strain of aerobic bacteria. It binds to magnesium which results in magnesium deficiency.
Learn moreVanilmandelate (VMA) and Homovanillate (HVA) are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.
Learn moreYour body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein. Inadequate vitamin B6 is one factor that leads to increased concentrations of kynurenate and xanthurenate in urine.
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