Alk Phos Isoenzyme

Serum

Performed by: LabCorp

The Alkaline Phosphatase Isoenzymes test offered by Labcorp is a diagnostic assay used to measure and differentiate the sources of elevated alkaline phosphatase (ALP) levels in the blood. This test is essential for identifying whether the elevation is due to liver, bone, or intestinal conditions.

Test Overview

Methodology: Electrophoresis
Specimen Required: Serum (1.6 mL; minimum 0.8 mL)
Collection Container: Red-top or gel-barrier tube
Stability:
- Room temperature: 7 days
- Refrigerated: 7 days
- Frozen: 3 months
Turnaround Time: 3–5 days
Patient Preparation: Fasting overnight is recommended, as eating, especially a fatty meal, may elevate intestinal ALP levels.

Isoenzyme Fractions and Reference Ranges

The test measures three ALP isoenzymes:

Liver Isoenzyme
- Males: 13% to 88% (depending on age)
- Females: 18% to 85% (depending on age)
Bone Isoenzyme
- Males: 12% to 68% (depending on age)
- Females: 14% to 68% (depending on age)
Intestinal Isoenzyme
- Males and Females: 0% to 18% (depending on age)

Clinical Applications

Liver Disorders: Elevated liver ALP may suggest conditions such as hepatitis, cirrhosis, or bile duct obstruction.
Bone Diseases: Increased bone ALP levels are linked to diseases like Paget's disease, osteomalacia, or bone metastases.
Intestinal Conditions: Elevated intestinal ALP can occur after a fatty meal, especially in individuals with specific blood types.

Important Notes

Specimen Requirements: Only serum samples are accepted; plasma or samples collected in EDTA, oxalate, or citrate tubes are unsuitable.
Test Interpretation: The results should be evaluated alongside other clinical data to determine the cause of elevated ALP levels.

Biomarkers included in this panel:

Bone Fraction

The Bone Fraction on Labcorp's Alkaline Phosphatase (ALP) Isoenzyme Panel represents the portion of alkaline phosphatase originating from bone tissue. Elevated levels of the bone fraction may indicate conditions such as Paget's disease, osteo

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Intestinal Frac

The Intestinal Fraction on Labcorp's Alkaline Phosphatase (ALP) Isoenzyme Panel represents the portion of alkaline phosphatase derived from the intestines. Elevated levels of the intestinal fraction may be observed after meals, especially in indi

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Liver Fraction

The Liver Fraction on Labcorp's Alkaline Phosphatase (ALP) Isoenzyme Panel refers to the specific portion of alkaline phosphatase that originates from the liver. This isoenzyme is measured to help assess liver function and diagnose liver-related

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Alk Phos Isoenzyme

Performed by: LabCorp

Test Overview

Isoenzyme Fractions and Reference Ranges

Clinical Applications

Important Notes

Biomarkers included in this panel:

Bone Fraction

Intestinal Frac

Liver Fraction

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